About Retinoschisin
Retinoschisin (RS1) is a protein
from Homo sapiens identified by UniProt accession
O15537, 224 residues long.
MolForge cross-references it against 0 known binders and
174 disease associations.
Target properties
| Protein name | Retinoschisin |
|---|
| UniProt accession | O15537 |
|---|
| Gene | RS1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 224 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (174)
Diseases linked to this target (Open Targets).
- X-linked retinoschisis · score 0.82
- retinoschisis · score 0.63
- Retinal dystrophy · score 0.55
- developmental and epileptic encephalopathy, 2 · score 0.45
- developmental and epileptic encephalopathy · score 0.45
- genetic disorder · score 0.40
- intellectual disability - sparse hair - brachydactyly · score 0.27
- Angelman syndrome · score 0.19
- atypical Rett syndrome · score 0.14
- Epileptic encephalopathy · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15537-F1 | alphafold | PREDICTED | 72.68 | — |
Amino-acid sequence (224 residues)
MSRKIEGFLL LLLFGYEATL GLSSTEDEGE DPWYQKACKC DCQGGPNALW SAGATSLDCI PECPYHKPLG FESGEVTPDQ ITCSNPEQYV GWYSSWTANK ARLNSQGFGC AWLSKFQDSS QWLQIDLKEI KVISGILTQG RCDIDEWMTK YSVQYRTDER LNWIYYKDQT GNNRVFYGNS DRTSTVQNLL RPPIISRFIR LIPLGWHVRI AIRMELLECV SKCA
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