About P2X purinoceptor 6
P2X purinoceptor 6 (P2RX6) is a protein
from Homo sapiens identified by UniProt accession
O15547, 441 residues long.
MolForge cross-references it against 0 known binders and
34 disease associations.
Target properties
| Protein name | P2X purinoceptor 6 |
|---|
| UniProt accession | O15547 |
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| Gene | P2RX6 |
|---|
| Organism | Homo sapiens |
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| Length | 441 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (34)
Diseases linked to this target (Open Targets).
- cutaneous melanoma · score 0.10
- renal cell carcinoma · score 0.07
- Inguinal hernia · score 0.04
- metabolite measurement · score 0.03
- 22q11.2 deletion syndrome · score 0.02
- myopathy · score 0.01
- Zinc deficiency · score 0.01
- Obesity · score 0.01
- cystic fibrosis · score 0.01
- cancer · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15547-F1 | alphafold | PREDICTED | 82.88 | — |
Amino-acid sequence (441 residues)
MCPQLAGAGS MGSPGATTGW GLLDYKTEKY VMTRNWRVGA LQRLLQFGIV VYVVGWALLA KKGYQERDLE PQFSIITKLK GVSVTQIKEL GNRLWDVADF VKPPQGENVF FLVTNFLVTP AQVQGRCPEH PSVPLANCWV DEDCPEGEGG THSHGVKTGQ CVVFNGTHRT CEIWSWCPVE SGVVPSRPLL AQAQNFTLFI KNTVTFSKFN FSKSNALETW DPTYFKHCRY EPQFSPYCPV FRIGDLVAKA GGTFEDLALL GGSVGIRVHW DCDLDTGDSG CWPHYSFQLQ EKSYNFRTAT HWWEQPGVEA RTLLKLYGIR FDILVTGQAG KFGLIPTAVT LGTGAAWLGV VTFFCDLLLL YVDREAHFYW RTKYEEAKAP KATANSVWRE LALASQARLA ECLRRSSAPA PTATAAGSQT QTPGWPCPSS DTHLPTHSGS L
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