About Claudin-3
Claudin-3 (CLDN3) is a protein
from Homo sapiens identified by UniProt accession
O15551, 220 residues long.
MolForge cross-references it against 0 known binders and
239 disease associations.
Target properties
| Protein name | Claudin-3 |
|---|
| UniProt accession | O15551 |
|---|
| Gene | CLDN3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 220 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (239)
Diseases linked to this target (Open Targets).
- platelet component distribution width · score 0.23
- mean platelet volume · score 0.21
- neoplasm · score 0.11
- non-small cell lung carcinoma · score 0.10
- hepatocellular carcinoma · score 0.09
- cancer · score 0.09
- Barrett's esophagus · score 0.08
- colitis · score 0.08
- triple-negative breast cancer · score 0.08
- AIDS dementia · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15551-F1 | alphafold | PREDICTED | 81.54 | — |
Amino-acid sequence (220 residues)
MSMGLEITGT ALAVLGWLGT IVCCALPMWR VSAFIGSNII TSQNIWEGLW MNCVVQSTGQ MQCKVYDSLL ALPQDLQAAR ALIVVAILLA AFGLLVALVG AQCTNCVQDD TAKAKITIVA GVLFLLAALL TLVPVSWSAN TIIRDFYNPV VPEAQKREMG AGLYVGWAAA ALQLLGGALL CCSCPPREKK YTATKVVYSA PRSTGPGASL GTGYDRKDYV
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