About Intermediate conductance calcium-activated potassium channel protein 4
Intermediate conductance calcium-activated potassium channel protein 4 (KCNN4) is a protein
from Homo sapiens identified by UniProt accession
O15554, 427 residues long.
MolForge cross-references it against 0 known binders and
349 disease associations.
Target properties
| Protein name | Intermediate conductance calcium-activated potassium channel protein 4 |
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| UniProt accession | O15554 |
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| Gene | KCNN4 |
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| Organism | Homo sapiens |
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| Length | 427 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (349)
Diseases linked to this target (Open Targets).
- dehydrated hereditary stomatocytosis · score 0.64
- cystic fibrosis · score 0.39
- pain · score 0.37
- mean corpuscular hemoglobin concentration · score 0.37
- osteoarthritis, hip · score 0.37
- alcohol abuse · score 0.37
- osteoarthritis, knee · score 0.37
- mean corpuscular volume · score 0.36
- monocyte count · score 0.35
- hemoglobin measurement · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15554-F1 | alphafold | PREDICTED | 84.19 | — |
Amino-acid sequence (427 residues)
MGGDLVLGLG ALRRRKRLLE QEKSLAGWAL VLAGTGIGLM VLHAEMLWFG GCSWALYLFL VKCTISISTF LLLCLIVAFH AKEVQLFMTD NGLRDWRVAL TGRQAAQIVL ELVVCGLHPA PVRGPPCVQD LGAPLTSPQP WPGFLGQGEA LLSLAMLLRL YLVPRAVLLR SGVLLNASYR SIGALNQVRF RHWFVAKLYM NTHPGRLLLG LTLGLWLTTA WVLSVAERQA VNATGHLSDT LWLIPITFLT IGYGDVVPGT MWGKIVCLCT GVMGVCCTAL LVAVVARKLE FNKAEKHVHN FMMDIQYTKE MKESAARVLQ EAWMFYKHTR RKESHAARRH QRKLLAAINA FRQVRLKHRK LREQVNSMVD ISKMHMILYD LQQNLSSSHR ALEKQIDTLA GKLDALTELL STALGPRQLP EPSQQSK
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