mRNA cap guanine-N(7) methyltransferase (RNMT)

About mRNA cap guanine-N(7) methyltransferase

mRNA cap guanine-N(7) methyltransferase (RNMT) is a protein from Homo sapiens identified by UniProt accession O43148, 476 residues long. MolForge cross-references it against 0 known binders and 53 disease associations.

Target properties

Protein name	mRNA cap guanine-N(7) methyltransferase
UniProt accession	O43148
Gene	RNMT
Organism	Homo sapiens
Length	476 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (53)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.54
HIV infection · score 0.37
wrist fracture · score 0.28
C-reactive protein measurement · score 0.23
alkaline phosphatase measurement · score 0.19
bone fracture · score 0.19
heel bone mineral density · score 0.19
clear cell renal carcinoma · score 0.17
femoral neck bone mineral density · score 0.16
bone quantitative ultrasound measurement · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43148-F1	alphafold	PREDICTED	77.39	—

Amino-acid sequence (476 residues)

MANSAKAEEY EKMSLEQAKA SVNSETESSF NINENTTASG TGLSEKTSVC RQVDIARKRK EFEDDLVKES SSCGKDTPSK KRKLDPEIVP EEKDCGDAEG NSKKRKRETE DVPKDKSSTG DGTQNKRKIA LEDVPEKQKN LEEGHSSTVA AHYNELQEVG LEKRSQSRIF YLRNFNNWMK SVLIGEFLEK VRQKKKRDIT VLDLGCGKGG DLLKWKKGRI NKLVCTDIAD VSVKQCQQRY EDMKNRRDSE YIFSAEFITA DSSKELLIDK FRDPQMCFDI CSCQFVCHYS FESYEQADMM LRNACERLSP GGYFIGTTPN SFELIRRLEA SETESFGNEI YTVKFQKKGD YPLFGCKYDF NLEGVVDVPE FLVYFPLLNE MAKKYNMKLV YKKTFLEFYE EKIKNNENKM LLKRMQALEP YPANESSKLV SEKVDDYEHA AKYMKNSQVR LPLGTLSKSE WEATSIYLVF AFEKQQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards