About Methylcytosine dioxygenase TET3
Methylcytosine dioxygenase TET3 (TET3) is a protein
from Homo sapiens identified by UniProt accession
O43151, 1795 residues long.
MolForge cross-references it against 0 known binders and
206 disease associations.
Target properties
| Protein name | Methylcytosine dioxygenase TET3 |
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| UniProt accession | O43151 |
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| Gene | TET3 |
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| Organism | Homo sapiens |
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| Length | 1795 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (206)
Diseases linked to this target (Open Targets).
- Beck-Fahrner syndrome · score 0.77
- genetic disorder · score 0.45
- eosinophil count · score 0.43
- complex neurodevelopmental disorder · score 0.37
- neurodegenerative disease · score 0.37
- protein measurement · score 0.35
- systemic lupus erythematosus · score 0.30
- eosinophil percentage of leukocytes · score 0.30
- Intellectual disability · score 0.26
- multiple myeloma · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43151-F1 | alphafold | PREDICTED | 51.89 | — |
Amino-acid sequence (1795 residues)
MSQFQVPLAV QPDLPGLYDF PQRQVMVGSF PGSGLSMAGS ESQLRGGGDG RKKRKRCGTC EPCRRLENCG ACTSCTNRRT HQICKLRKCE VLKKKVGLLK EVEIKAGEGA GPWGQGAAVK TGSELSPVDG PVPGQMDSGP VYHGDSRQLS ASGVPVNGAR EPAGPSLLGT GGPWRVDQKP DWEAAPGPAH TARLEDAHDL VAFSAVAEAV SSYGALSTRL YETFNREMSR EAGNNSRGPR PGPEGCSAGS EDLDTLQTAL ALARHGMKPP NCNCDGPECP DYLEWLEGKI KSVVMEGGEE RPRLPGPLPP GEAGLPAPST RPLLSSEVPQ ISPQEGLPLS QSALSIAKEK NISLQTAIAI EALTQLSSAL PQPSHSTPQA SCPLPEALSP PAPFRSPQSY LRAPSWPVVP PEEHSSFAPD SSAFPPATPR TEFPEAWGTD TPPATPRSSW PMPRPSPDPM AELEQLLGSA SDYIQSVFKR PEALPTKPKV KVEAPSSSPA PAPSPVLQRE APTPSSEPDT HQKAQTALQQ HLHHKRSLFL EQVHDTSFPA PSEPSAPGWW PPPSSPVPRL PDRPPKEKKK KLPTPAGGPV GTEKAAPGIK PSVRKPIQIK KSRPREAQPL FPPVRQIVLE GLRSPASQEV QAHPPAPLPA SQGSAVPLPP EPSLALFAPS PSRDSLLPPT QEMRSPSPMT ALQPGSTGPL PPADDKLEEL IRQFEAEFGD SFGLPGPPSV PIQDPENQQT CLPAPESPFA TRSPKQIKIE SSGAVTVLST TCFHSEEGGQ EATPTKAENP LTPTLSGFLE SPLKYLDTPT KSLLDTPAKR AQAEFPTCDC VEQIVEKDEG PYYTHLGSGP TVASIRELME ERYGEKGKAI RIEKVIYTGK EGKSSRGCPI AKWVIRRHTL EEKLLCLVRH RAGHHCQNAV IVILILAWEG IPRSLGDTLY QELTDTLRKY GNPTSRRCGL NDDRTCACQG KDPNTCGASF SFGCSWSMYF NGCKYARSKT PRKFRLAGDN PKEEEVLRKS FQDLATEVAP LYKRLAPQAY QNQVTNEEIA IDCRLGLKEG RPFAGVTACM DFCAHAHKDQ HNLYNGCTVV CTLTKEDNRC VGKIPEDEQL HVLPLYKMAN TDEFGSEENQ NAKVGSGAIQ VLTAFPREVR RLPEPAKSCR QRQLEARKAA AEKKKIQKEK LSTPEKIKQE ALELAGITSD PGLSLKGGLS QQGLKPSLKV EPQNHFSSFK YSGNAVVESY SVLGNCRPSD PYSMNSVYSY HSYYAQPSLT SVNGFHSKYA LPSFSYYGFP SSNPVFPSQF LGPGAWGHSG SSGSFEKKPD LHALHNSLSP AYGGAEFAEL PSQAVPTDAH HPTPHHQQPA YPGPKEYLLP KAPLLHSVSR DPSPFAQSSN CYNRSIKQEP VDPLTQAEPV PRDAGKMGKT PLSEVSQNGG PSHLWGQYSG GPSMSPKRTN GVGGSWGVFS SGESPAIVPD KLSSFGASCL APSHFTDGQW GLFPGEGQQA ASHSGGRLRG KPWSPCKFGN STSALAGPSL TEKPWALGAG DFNSALKGSP GFQDKLWNPM KGEEGRIPAA GASQLDRAWQ SFGLPLGSSE KLFGALKSEE KLWDPFSLEE GPAEEPPSKG AVKEEKGGGG AEEEEEELWS DSEHNFLDEN IGGVAVAPAH GSILIECARR ELHATTPLKK PNRCHPTRIS LVFYQHKNLN QPNHGLALWE AKMKQLAERA RARQEEAARL GLGQQEAKLY GKKRKWGGTV VAEPQQKEKK GVVPTRQALA VPTDSAVTVS SYAYTKVTGP YSRWI
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