Ribosomal RNA-processing protein 8 (RRP8)

About Ribosomal RNA-processing protein 8

Ribosomal RNA-processing protein 8 (RRP8) is a protein from Homo sapiens identified by UniProt accession O43159, 456 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.

Target properties

Protein name	Ribosomal RNA-processing protein 8
UniProt accession	O43159
Gene	RRP8
Organism	Homo sapiens
Length	456 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (24)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.49
autism spectrum disorder · score 0.33
endometrial cancer · score 0.13
hepatocellular carcinoma · score 0.08
hyperinsulinism due to INSR deficiency · score 0.04
Systemic lupus erythematosus · score 0.03
papillary thyroid carcinoma · score 0.02
cancer · score 0.02
neoplasm · score 0.02
rheumatic disease · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43159-F1	alphafold	PREDICTED	72.13	—

Amino-acid sequence (456 residues)

MFEEPEWAEA APVAAGLGPV ISRPPPAASS QNKGSKRRQL LATLRALEAA SLSQHPPSLC ISDSEEEEEE RKKKCPKKAS FASASAEVGK KGKKKCQKQG PPCSDSEEEV ERKKKCHKQA LVGSDSAEDE KRKRKCQKHA PINSAQHLDN VDQTGPKAWK GSTTNDPPKQ SPGSTSPKPP HTLSRKQWRN RQKNKRRCKN KFQPPQVPDQ APAEAPTEKT EVSPVPRTDS HEARAGALRA RMAQRLDGAR FRYLNEQLYS GPSSAAQRLF QEDPEAFLLY HRGFQSQVKK WPLQPVDRIA RDLRQRPASL VVADFGCGDC RLASSIRNPV HCFDLASLDP RVTVCDMAQV PLEDESVDVA VFCLSLMGTN IRDFLEEANR VLKPGGLLKV AEVSSRFEDV RTFLRAVTKL GFKIVSKDLT NSHFFLFDFQ KTGPPLVGPK AQLSGLQLQP CLYKRR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards