About U4/U6 small nuclear ribonucleoprotein Prp4
U4/U6 small nuclear ribonucleoprotein Prp4 (PRPF4) is a protein
from Homo sapiens identified by UniProt accession
O43172, 522 residues long.
MolForge cross-references it against 0 known binders and
28 disease associations.
Target properties
| Protein name | U4/U6 small nuclear ribonucleoprotein Prp4 |
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| UniProt accession | O43172 |
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| Gene | PRPF4 |
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| Organism | Homo sapiens |
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| Length | 522 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (28)
Diseases linked to this target (Open Targets).
- retinitis pigmentosa · score 0.60
- neurodegenerative disease · score 0.20
- inherited retinal dystrophy · score 0.18
- Retinal dystrophy · score 0.17
- neutrophil count · score 0.14
- appendicular lean mass · score 0.12
- body fat percentage · score 0.09
- reticulocyte count · score 0.08
- reticulocyte measurement · score 0.07
- leukocyte count · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43172-F1 | alphafold | PREDICTED | 82.05 | — |
Amino-acid sequence (522 residues)
MASSRASSTQ ATKTKAPDDL VAPVVKKPHI YYGSLEEKER ERLAKGESGI LGKDGLKAGI EAGNINITSG EVFEIEEHIS ERQAEVLAEF ERRKRARQIN VSTDDSEVKA CLRALGEPIT LFGEGPAERR ERLRNILSVV GTDALKKTKK DDEKSKKSKE EYQQTWYHEG PNSLKVARLW IANYSLPRAM KRLEEARLHK EIPETTRTSQ MQELHKSLRS LNNFCSQIGD DRPISYCHFS PNSKMLATAC WSGLCKLWSV PDCNLLHTLR GHNTNVGAIV FHPKSTVSLD PKDVNLASCA ADGSVKLWSL DSDEPVADIE GHTVRVARVM WHPSGRFLGT TCYDRSWRLW DLEAQEEILH QEGHSMGVYD IAFHQDGSLA GTGGLDAFGR VWDLRTGRCI MFLEGHLKEI YGINFSPNGY HIATGSGDNT CKVWDLRQRR CVYTIPAHQN LVTGVKFEPI HGNFLLTGAY DNTAKIWTHP GWSPLKTLAG HEGKVMGLDI SSDGQLIATC SYDRTFKLWM AE
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