About Cytochrome P450 26A1
Cytochrome P450 26A1 (CYP26A1) is a protein
from Homo sapiens identified by UniProt accession
O43174, 497 residues long.
MolForge cross-references it against 0 known binders and
181 disease associations.
Target properties
| Protein name | Cytochrome P450 26A1 |
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| UniProt accession | O43174 |
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| Gene | CYP26A1 |
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| Organism | Homo sapiens |
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| Length | 497 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (181)
Diseases linked to this target (Open Targets).
- triglyceride measurement · score 0.42
- platelet count · score 0.41
- high density lipoprotein cholesterol measurement · score 0.41
- low density lipoprotein cholesterol measurement · score 0.40
- alcohol drinking · score 0.39
- alcohol consumption measurement · score 0.38
- sex hormone-binding globulin measurement · score 0.38
- bilirubin measurement · score 0.38
- glomerular filtration rate · score 0.38
- serum gamma-glutamyl transferase measurement · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43174-F1 | alphafold | PREDICTED | 89.36 | — |
Amino-acid sequence (497 residues)
MGLPALLASA LCTFVLPLLL FLAAIKLWDL YCVSGRDRSC ALPLPPGTMG FPFFGETLQM VLQRRKFLQM KRRKYGFIYK THLFGRPTVR VMGADNVRRI LLGEHRLVSV HWPASVRTIL GSGCLSNLHD SSHKQRKKVI MRAFSREALE CYVPVITEEV GSSLEQWLSC GERGLLVYPE VKRLMFRIAM RILLGCEPQL AGDGDSEQQL VEAFEEMTRN LFSLPIDVPF SGLYRGMKAR NLIHARIEQN IRAKICGLRA SEAGQGCKDA LQLLIEHSWE RGERLDMQAL KQSSTELLFG GHETTASAAT SLITYLGLYP HVLQKVREEL KSKGLLCKSN QDNKLDMEIL EQLKYIGCVI KETLRLNPPV PGGFRVALKT FELNGYQIPK GWNVIYSICD THDVAEIFTN KEEFNPDRFM LPHPEDASRF SFIPFGGGLR SCVGKEFAKI LLKIFTVELA RHCDWQLLNG PPTMKTSPTV YPVDNLPARF THFHGEI
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