D-3-phosphoglycerate dehydrogenase (PHGDH)

About D-3-phosphoglycerate dehydrogenase

D-3-phosphoglycerate dehydrogenase (PHGDH) is a protein from Homo sapiens identified by UniProt accession O43175, 533 residues long. MolForge cross-references it against 0 known binders and 324 disease associations.

Target properties

Protein name	D-3-phosphoglycerate dehydrogenase
UniProt accession	O43175
Gene	PHGDH
Organism	Homo sapiens
Length	533 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (324)

Diseases linked to this target (Open Targets).

PHGDH deficiency · score 0.81
Neu-Laxova syndrome 1 · score 0.77
3-phosphoglycerate dehydrogenase deficiency, infantile/juvenile form · score 0.76
Neu-Laxova syndrome · score 0.50
hemoglobin measurement · score 0.43
body height · score 0.43
genetic disorder · score 0.41
erythrocyte count · score 0.41
hematocrit · score 0.40
urate measurement · score 0.40

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43175-F1	alphafold	PREDICTED	92.93	—

Amino-acid sequence (533 residues)

MAFANLRKVL ISDSLDPCCR KILQDGGLQV VEKQNLSKEE LIAELQDCEG LIVRSATKVT ADVINAAEKL QVVGRAGTGV DNVDLEAATR KGILVMNTPN GNSLSAAELT CGMIMCLARQ IPQATASMKD GKWERKKFMG TELNGKTLGI LGLGRIGREV ATRMQSFGMK TIGYDPIISP EVSASFGVQQ LPLEEIWPLC DFITVHTPLL PSTTGLLNDN TFAQCKKGVR VVNCARGGIV DEGALLRALQ SGQCAGAALD VFTEEPPRDR ALVDHENVIS CPHLGASTKE AQSRCGEEIA VQFVDMVKGK SLTGVVNAQA LTSAFSPHTK PWIGLAEALG TLMRAWAGSP KGTIQVITQG TSLKNAGNCL SPAVIVGLLK EASKQADVNL VNAKLLVKEA GLNVTTSHSP AAPGEQGFGE CLLAVALAGA PYQAVGLVQG TTPVLQGLNG AVFRPEVPLR RDLPLLLFRT QTSDPAMLPT MIGLLAEAGV RLLSYQTSLV SDGETWHVMG ISSLLPSLEA WKQHVTEAFQ FHF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards