NADH dehydrogenase [ubiquinone] iron-sulfur protein…

About NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (NDUFS4) is a protein from Homo sapiens identified by UniProt accession O43181, 175 residues long. MolForge cross-references it against 0 known binders and 423 disease associations.

Target properties

Protein name	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
UniProt accession	O43181
Gene	NDUFS4
Organism	Homo sapiens
Length	175 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (423)

Diseases linked to this target (Open Targets).

Leigh syndrome · score 0.77
mitochondrial complex I deficiency · score 0.77
type 2 diabetes mellitus · score 0.62
diabetes mellitus · score 0.61
polycystic ovary syndrome · score 0.60
type 1 diabetes mellitus · score 0.58
gestational diabetes · score 0.58
obesity · score 0.57
prediabetes syndrome · score 0.56
schizophrenia · score 0.55

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43181-F1	alphafold	PREDICTED	84.10	—

Amino-acid sequence (175 residues)

MAAVSMSVVL RQTLWRRRAV AVAALSVSRV PTRSLRTSTW RLAQDQTQDT QLITVDEKLD ITTLTGVPEE HIKTRKVRIF VPARNNMQSG VNNTKKWKME FDTRERWENP LMGWASTADP LSNMVLTFST KEDAVSFAEK NGWSYDIEER KVPKPKSKSY GANFSWNKRT RVSTK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (NDUFS4)