Cone-rod homeobox protein (CRX)

About Cone-rod homeobox protein

Cone-rod homeobox protein (CRX) is a protein from Homo sapiens identified by UniProt accession O43186, 299 residues long. MolForge cross-references it against 0 known binders and 268 disease associations.

Target properties

Protein name	Cone-rod homeobox protein
UniProt accession	O43186
Gene	CRX
Organism	Homo sapiens
Length	299 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (268)

Diseases linked to this target (Open Targets).

Cone rod dystrophy · score 0.78
Leber congenital amaurosis · score 0.73
retinitis pigmentosa · score 0.71
autosomal dominant retinitis pigmentosa · score 0.56
Retinal dystrophy · score 0.56
neurodegenerative disease · score 0.53
benign concentric annular macular dystrophy · score 0.46
Stargardt disease · score 0.45
Macular dystrophy · score 0.44
Leber congenital amaurosis 1 · score 0.43

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43186-F1	alphafold	PREDICTED	60.52	—

Amino-acid sequence (299 residues)

MMAYMNPGPH YSVNALALSG PSVDLMHQAV PYPSAPRKQR RERTTFTRSQ LEELEALFAK TQYPDVYARE EVALKINLPE SRVQVWFKNR RAKCRQQRQQ QKQQQQPPGG QAKARPAKRK AGTSPRPSTD VCPDPLGISD SYSPPLPGPS GSPTTAVATV SIWSPASESP LPEAQRAGLV ASGPSLTSAP YAMTYAPASA FCSSPSAYGS PSSYFSGLDP YLSPMVPQLG GPALSPLSGP SVGPSLAQSP TSLSGQSYGA YSPVDSLEFK DPTGTWKFTY NPMDPLDYKD QSAWKFQIL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards