PHD finger protein 1 (PHF1)

About PHD finger protein 1

PHD finger protein 1 (PHF1) is a protein from Homo sapiens identified by UniProt accession O43189, 567 residues long. MolForge cross-references it against 0 known binders and 105 disease associations.

Target properties

Protein name	PHD finger protein 1
UniProt accession	O43189
Gene	PHF1
Organism	Homo sapiens
Length	567 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (105)

Diseases linked to this target (Open Targets).

Sacroiliac arthritis · score 0.14
neoplasm · score 0.08
lung adenocarcinoma · score 0.08
axial length measurement · score 0.07
lymphocyte count · score 0.06
cancer · score 0.05
type 1 diabetes mellitus · score 0.04
sex hormone-binding globulin measurement · score 0.03
diet measurement · score 0.03
schizophrenia · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43189-F1	alphafold	PREDICTED	71.00	—

Amino-acid sequence (567 residues)

MAQPPRLSRS GASSLWDPAS PAPTSGPRPR LWEGQDVLAR WTDGLLYLGT IKKVDSAREV CLVQFEDDSQ FLVLWKDISP AALPGEELLC CVCRSETVVP GNRLVSCEKC RHAYHQDCHV PRAPAPGEGE GTSWVCRQCV FAIATKRGGA LKKGPYARAM LGMKLSLPYG LKGLDWDAGH LSNRQQSYCY CGGPGEWNLK MLQCRSCLQW FHEACTQCLS KPLLYGDRFY EFECCVCRGG PEKVRRLQLR WVDVAHLVLY HLSVCCKKKY FDFDREILPF TSENWDSLLL GELSDTPKGE RSSRLLSALN SHKDRFISGR EIKKRKCLFG LHARMPPPVE PPTGDGALTS FPSGQGPGGG VSRPLGKRRR PEPEPLRRRQ KGKVEELGPP SAVRNQPEPQ EQRERAHLQR ALQASVSPPS PSPNQSYQGS SGYNFRPTDA RCLPSSPIRM FASFHPSAST AGTSGDSGPP DRSPLELHIG FPTDIPKSAP HSMTASSSSV SSPSPGLPRR SAPPSPLCRS LSPGTGGGVR GGVGYLSRGD PVRVLARRVR PDGSVQYLVE WGGGGIF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards