About Motilin receptor
Motilin receptor (MLNR) is a protein
from Homo sapiens identified by UniProt accession
O43193, 412 residues long.
MolForge cross-references it against 0 known binders and
50 disease associations.
Target properties
| Protein name | Motilin receptor |
|---|
| UniProt accession | O43193 |
|---|
| Gene | MLNR |
|---|
| Organism | Homo sapiens |
|---|
| Length | 412 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (50)
Diseases linked to this target (Open Targets).
- ovarian cancer · score 0.26
- head and neck squamous cell carcinoma · score 0.16
- gastroparesis · score 0.12
- IGF-1 measurement · score 0.09
- cystatin C measurement · score 0.09
- insulin like growth factor measurement · score 0.06
- body height · score 0.04
- leukocyte count · score 0.03
- intrahepatic cholangiocarcinoma · score 0.03
- neutrophil count · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43193-F1 | alphafold | PREDICTED | 77.16 | — |
Amino-acid sequence (412 residues)
MGSPWNGSDG PEGAREPPWP ALPPCDERRC SPFPLGALVP VTAVCLCLFV VGVSGNVVTV MLIGRYRDMR TTTNLYLGSM AVSDLLILLG LPFDLYRLWR SRPWVFGPLL CRLSLYVGEG CTYATLLHMT ALSVERYLAI CRPLRARVLV TRRRVRALIA VLWAVALLSA GPFLFLVGVE QDPGISVVPG LNGTARIASS PLASSPPLWL SRAPPPSPPS GPETAEAAAL FSRECRPSPA QLGALRVMLW VTTAYFFLPF LCLSILYGLI GRELWSSRRP LRGPAASGRE RGHRQTVRVL LVVVLAFIIC WLPFHVGRII YINTEDSRMM YFSQYFNIVA LQLFYLSASI NPILYNLISK KYRAAAFKLL LARKSRPRGF HRSRDTAGEV AGDTGGDTVG YTETSANVKT MG
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