About G-protein coupled receptor 39
G-protein coupled receptor 39 (GPR39) is a protein
from Homo sapiens identified by UniProt accession
O43194, 453 residues long.
MolForge cross-references it against 0 known binders and
141 disease associations.
Target properties
| Protein name | G-protein coupled receptor 39 |
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| UniProt accession | O43194 |
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| Gene | GPR39 |
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| Organism | Homo sapiens |
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| Length | 453 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (141)
Diseases linked to this target (Open Targets).
- calcium measurement · score 0.40
- serum gamma-glutamyl transferase measurement · score 0.39
- hypertension · score 0.30
- prostate adenocarcinoma · score 0.10
- esophageal squamous cell carcinoma · score 0.08
- hepatocellular carcinoma · score 0.08
- MODY · score 0.07
- drug use measurement · score 0.07
- hyperinsulinism due to INSR deficiency · score 0.06
- exercise-induced hyperinsulinism · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43194-F1 | alphafold | PREDICTED | 76.08 | — |
Amino-acid sequence (453 residues)
MASPSLPGSD CSQIIDHSHV PEFEVATWIK ITLILVYLII FVMGLLGNSA TIRVTQVLQK KGYLQKEVTD HMVSLACSDI LVFLIGMPME FYSIIWNPLT TSSYTLSCKL HTFLFEACSY ATLLHVLTLS FERYIAICHP FRYKAVSGPC QVKLLIGFVW VTSALVALPL LFAMGTEYPL VNVPSHRGLT CNRSSTRHHE QPETSNMSIC TNLSSRWTVF QSSIFGAFVV YLVVLLSVAF MCWNMMQVLM KSQKGSLAGG TRPPQLRKSE SEESRTARRQ TIIFLRLIVV TLAVCWMPNQ IRRIMAAAKP KHDWTRSYFR AYMILLPFSE TFFYLSSVIN PLLYTVSSQQ FRRVFVQVLC CRLSLQHANH EKRLRVHAHS TTDSARFVQR PLLFASRRQS SARRTEKIFL STFQSEAEPQ SKSQSLSLES LEPNSGAKPA NSAAENGFQE HEV
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