About Septin-4
Septin-4 (SEPTIN4) is a protein
from Homo sapiens identified by UniProt accession
O43236, 996 residues long.
MolForge cross-references it against 0 known binders and
216 disease associations.
Target properties
| Protein name | Septin-4 |
|---|
| UniProt accession | O43236 |
|---|
| Gene | SEPTIN4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 996 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (216)
Diseases linked to this target (Open Targets).
- male infertility due to globozoospermia · score 0.39
- refractive error · score 0.23
- body height · score 0.21
- age at first birth measurement · score 0.14
- HbA1c measurement · score 0.13
- refractive error measurement · score 0.13
- urate measurement · score 0.11
- glomerular filtration rate · score 0.11
- azoospermia · score 0.11
- male infertility with teratozoospermia due to single gene mutation · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43236-F1 | alphafold | PREDICTED | 71.46 | — |
Amino-acid sequence (996 residues)
MVKTNKPGAK VAVSAQRGSE VTTNTSPQQG HGYVLASSHR SAAVSLNPSH RRSEAAHPTT PHSASDYPRS VSLQSGPGHY AVPTPRGPET GPRTESSRHS SPHLKSQKTQ TLASHASSRQ WKVSPPREEA ARRGSESKSG REVGHHASSI PDAKSTHQLS FQDQKNNLQS QILEDDPPSK VQNPQGVRVP RRILSYPKDE AVQTEPIQRI TTTSEIRSPR SPSLLEHGSS CVSADYQTAQ RRVPVEESET GPYGPIPSKP KALYRNMNLD SLLKLSVLKD SDGVHRVSAR VDPESLHKYS AYPETKPSAK VLVSSQVESN VRTPIRGNSE VGRRVTISPG VQSVEPTHHV TVPSVSEGSH KSSMFVTPEP IYKQQTQKPP EITYMSQGPT PRYPELSQKP SIHAELELTP RPLPPRSLPR YGPDSSWWPL LNPEVETPQS QLTTPDFEPK CSPSLDLLLS GFKIDSSPFC EDLKFQREKA SLSPPSPPKE FPSWAPLSEV PQTPKHTCKQ PIQRFTAFFL DVSEEMYNRV IWWLKDEEIK RFLEDTTDDG ELSKFVKDFS GNASCHPPEA KTWASRPQVP EPRPQAPDLY DDDLEFRPPS RPQSSDNQQY FCAPAPLSPS ARPRSPWGKL DPYDSSEDDK EYVGFATLPN QVHRKSVKKG FDFTLMVAGE SGLGKSTLVN SLFLTDLYRD RKLLGAEERI MQTVEITKHA VDIEEKGVRL RLTIVDTPGF GDAVNNTECW KPVAEYIDQQ FEQYFRDESG LNRKNIQDNR VHCCLYFISP FGHGLRPLDV EFMKALHQRV NIVPILAKAD TLTPPEVDHK KRKIREEIEH FGIKIYQFPD CDSDEDEDFK LQDQALKESI PFAVIGSNTV VEARGRRVRG RLYPWGIVEV ENPGHCDFVK LRTMLVRTHM QDLKDVTRET HYENYRAQCI QSMTRLVVKE RNRNKLTRES GTDFPIPAVP PGTDPETEKL IREKDEELRR MQEMLHKIQK QMKENY
Explore Septin-4 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets