About Cytoplasmic dynein 1 light intermediate chain 2
Cytoplasmic dynein 1 light intermediate chain 2 (DYNC1LI2) is a protein
from Homo sapiens identified by UniProt accession
O43237, 492 residues long.
MolForge cross-references it against 0 known binders and
92 disease associations.
Target properties
| Protein name | Cytoplasmic dynein 1 light intermediate chain 2 |
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| UniProt accession | O43237 |
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| Gene | DYNC1LI2 |
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| Organism | Homo sapiens |
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| Length | 492 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (92)
Diseases linked to this target (Open Targets).
- viral disease · score 0.46
- breast adenocarcinoma · score 0.10
- high density lipoprotein cholesterol measurement · score 0.10
- self reported educational attainment · score 0.09
- azoospermia · score 0.09
- Male infertility with spermatogenesis disorder due to single gene mutation · score 0.07
- systolic blood pressure · score 0.07
- Female infertility due to fertilization defect · score 0.07
- Rare genetic female infertility · score 0.07
- partial chromosome Y deletion · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43237-F1 | alphafold | PREDICTED | 61.51 | — |
Amino-acid sequence (492 residues)
MAPVGVEKKL LLGPNGPAVA AAGDLTSEEE EGQSLWSSIL SEVSTRARSK LPSGKNILVF GEDGSGKTTL MTKLQGAEHG KKGRGLEYLY LSVHDEDRDD HTRCNVWILD GDLYHKGLLK FAVSAESLPE TLVIFVADMS RPWTVMESLQ KWASVLREHI DKMKIPPEKM RELERKFVKD FQDYMEPEEG CQGSPQRRGP LTSGSDEENV ALPLGDNVLT HNLGIPVLVV CTKCDAVSVL EKEHDYRDEH LDFIQSHLRR FCLQYGAALI YTSVKEEKNL DLLYKYIVHK TYGFHFTTPA LVVEKDAVFI PAGWDNEKKI AILHENFTTV KPEDAYEDFI VKPPVRKLVH DKELAAEDEQ VFLMKQQSLL AKQPATPTRA SESPARGPSG SPRTQGRGGP ASVPSSSPGT SVKKPDPNIK NNAASEGVLA SFFNSLLSKK TGSPGSPGAG GVQSTAKKSG QKTVLSNVQE ELDRMTRKPD SMVTNSSTEN EA
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