About Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPSS1) is a protein
from Homo sapiens identified by UniProt accession
O43252, 624 residues long.
MolForge cross-references it against 0 known binders and
44 disease associations.
Target properties
| Protein name | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 |
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| UniProt accession | O43252 |
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| Gene | PAPSS1 |
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| Organism | Homo sapiens |
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| Length | 624 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (44)
Diseases linked to this target (Open Targets).
- cancer · score 0.54
- Alzheimer disease · score 0.34
- lysosomal storage disease · score 0.33
- neurodegenerative disease · score 0.33
- Parkinson disease · score 0.33
- multiple sclerosis · score 0.33
- neutrophil count · score 0.29
- PHF-tau measurement · score 0.27
- pancreatic adenocarcinoma · score 0.26
- thyroid gland adenocarcinoma · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43252-F1 | alphafold | PREDICTED | 93.50 | — |
Amino-acid sequence (624 residues)
MEIPGSLCKK VKLSNNAQNW GMQRATNVTY QAHHVSRNKR GQVVGTRGGF RGCTVWLTGL SGAGKTTVSM ALEEYLVCHG IPCYTLDGDN IRQGLNKNLG FSPEDREENV RRIAEVAKLF ADAGLVCITS FISPYTQDRN NARQIHEGAS LPFFEVFVDA PLHVCEQRDV KGLYKKARAG EIKGFTGIDS EYEKPEAPEL VLKTDSCDVN DCVQQVVELL QERDIVPVDA SYEVKELYVP ENKLHLAKTD AETLPALKIN KVDMQWVQVL AEGWATPLNG FMREREYLQC LHFDCLLDGG VINLSVPIVL TATHEDKERL DGCTAFALMY EGRRVAILRN PEFFEHRKEE RCARQWGTTC KNHPYIKMVM EQGDWLIGGD LQVLDRVYWN DGLDQYRLTP TELKQKFKDM NADAVFAFQL RNPVHNGHAL LMQDTHKQLL ERGYRRPVLL LHPLGGWTKD DDVPLMWRMK QHAAVLEEGV LNPETTVVAI FPSPMMYAGP TEVQWHCRAR MVAGANFYIV GRDPAGMPHP ETGKDLYEPS HGAKVLTMAP GLITLEIVPF RVAAYNKKKK RMDYYDSEHH EDFEFISGTR MRKLAREGQK PPEGFMAPKA WTVLTEYYKS LEKA
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