About E3 ubiquitin-protein ligase SIAH2
E3 ubiquitin-protein ligase SIAH2 (SIAH2) is a protein
from Homo sapiens identified by UniProt accession
O43255, 324 residues long.
MolForge cross-references it against 0 known binders and
99 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase SIAH2 |
|---|
| UniProt accession | O43255 |
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| Gene | SIAH2 |
|---|
| Organism | Homo sapiens |
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| Length | 324 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (99)
Diseases linked to this target (Open Targets).
- breast carcinoma · score 0.36
- ovarian cancer · score 0.23
- clear cell renal carcinoma · score 0.18
- neoplasm · score 0.10
- cancer · score 0.09
- protein measurement · score 0.08
- hepatocellular carcinoma · score 0.08
- cholangiocarcinoma · score 0.08
- Red cell distribution width · score 0.07
- Hypoglycemia · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43255-F1 | alphafold | PREDICTED | 83.17 | — |
Amino-acid sequence (324 residues)
MSRPSSTGPS ANKPCSKQPP PQPQHTPSPA APPAAATISA AGPGSSAVPA AAAVISGPGG GGGAGPVSPQ HHELTSLFEC PVCFDYVLPP ILQCQAGHLV CNQCRQKLSC CPTCRGALTP SIRNLAMEKV ASAVLFPCKY ATTGCSLTLH HTEKPEHEDI CEYRPYSCPC PGASCKWQGS LEAVMSHLMH AHKSITTLQG EDIVFLATDI NLPGAVDWVM MQSCFGHHFM LVLEKQEKYE GHQQFFAIVL LIGTRKQAEN FAYRLELNGN RRRLTWEATP RSIHDGVAAA IMNSDCLVFD TAIAHLFADN GNLGINVTIS TCCP
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