Zinc finger HIT domain-containing protein 1 (ZNHIT1)

About Zinc finger HIT domain-containing protein 1

Zinc finger HIT domain-containing protein 1 (ZNHIT1) is a protein from Homo sapiens identified by UniProt accession O43257, 154 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.

Target properties

Protein name	Zinc finger HIT domain-containing protein 1
UniProt accession	O43257
Gene	ZNHIT1
Organism	Homo sapiens
Length	154 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (22)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.30
serum alanine aminotransferase measurement · score 0.17
mean corpuscular hemoglobin · score 0.08
breast cancer · score 0.05
hemoglobin measurement · score 0.04
hypoparathyroidism, familial isolated, 2 · score 0.03
mean corpuscular volume · score 0.03
acute myeloid leukemia · score 0.02
cancer · score 0.01
microphthalmia · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43257-F1	alphafold	PREDICTED	74.26	—

Amino-acid sequence (154 residues)

MVEKKTSVRS QDPGQRRVLD RAARQRRINR QLEALENDNF QDDPHAGLPQ LGKRLPQFDD DADTGKKKKK TRGDHFKLRF RKNFQALLEE QNLSVAEGPN YLTACAGPPS RPQRPFCAVC GFPSPYTCVS CGARYCTVRC LGTHQETRCL KWTV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards