About Proline dehydrogenase 1, mitochondrial
Proline dehydrogenase 1, mitochondrial (PRODH) is a protein
from Homo sapiens identified by UniProt accession
O43272, 600 residues long.
MolForge cross-references it against 0 known binders and
199 disease associations.
Target properties
| Protein name | Proline dehydrogenase 1, mitochondrial |
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| UniProt accession | O43272 |
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| Gene | PRODH |
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| Organism | Homo sapiens |
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| Length | 600 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (199)
Diseases linked to this target (Open Targets).
- hyperprolinemia type 1 · score 0.81
- amino acid measurement · score 0.53
- proline measurement · score 0.51
- serum metabolite measurement · score 0.49
- genetic disorder · score 0.48
- platelet count · score 0.46
- sex hormone-binding globulin measurement · score 0.42
- alanine measurement · score 0.41
- heel bone mineral density · score 0.41
- blood metabolite measurement · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43272-F1 | alphafold | PREDICTED | 84.46 | — |
Amino-acid sequence (600 residues)
MALRRALPAL RPCIPRFVPL STAPASREQP AAGPAAVPGG GSATAVRPPV PAVDFGNAQE AYRSRRTWEL ARSLLVLRLC AWPALLARHE QLLYVSRKLL GQRLFNKLMK MTFYGHFVAG EDQESIQPLL RHYRAFGVSA ILDYGVEEDL SPEEAEHKEM ESCTSAAERD GSGTNKRDKQ YQAHWAFGDR RNGVISARTY FYANEAKCDS HMETFLRCIE ASGRVSDDGF IAIKLTALGR PQFLLQFSEV LAKWRCFFHQ MAVEQGQAGL AAMDTKLEVA VLQESVAKLG IASRAEIEDW FTAETLGVSG TMDLLDWSSL IDSRTKLSKH LVVPNAQTGQ LEPLLSRFTE EEELQMTRML QRMDVLAKKA TEMGVRLMVD AEQTYFQPAI SRLTLEMQRK FNVEKPLIFN TYQCYLKDAY DNVTLDVELA RREGWCFGAK LVRGAYLAQE RARAAEIGYE DPINPTYEAT NAMYHRCLDY VLEELKHNAK AKVMVASHNE DTVRFALRRM EELGLHPADH RVYFGQLLGM CDQISFPLGQ AGYPVYKYVP YGPVMEVLPY LSRRALENSS LMKGTHRERQ LLWLELLRRL RTGNLFHRPA
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