About Trehalase
Trehalase (TREH) is a protein
from Homo sapiens identified by UniProt accession
O43280, 583 residues long.
MolForge cross-references it against 0 known binders and
112 disease associations.
Target properties
| Protein name | Trehalase |
|---|
| UniProt accession | O43280 |
|---|
| Gene | TREH |
|---|
| Organism | Homo sapiens |
|---|
| Length | 583 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (112)
Diseases linked to this target (Open Targets).
- diarrhea-vomiting due to trehalase deficiency · score 0.43
- alkaline phosphatase measurement · score 0.34
- cortical surface area measurement · score 0.31
- heel bone mineral density · score 0.29
- neurodegenerative disease · score 0.29
- celiac disease · score 0.24
- serum metabolite measurement · score 0.24
- serum non-albumin protein measurement · score 0.21
- bone quantitative ultrasound measurement · score 0.21
- blood urea nitrogen measurement · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43280-F1 | alphafold | PREDICTED | 92.39 | — |
Amino-acid sequence (583 residues)
MPGRTWELCL LLLLGLGLGS QEALPPPCES EIYCHGELLN QVQMAKLYQD DKQFVDMPLS IAPEQVLQTF TELSRDHNHS IPREQLQAFV HEHFQAKGQE LQPWTPADWK DSPQFLQKIS DAKLRAWAGQ LHQLWKKLGK KMKPEVLSHP ERFSLIYSEH PFIVPGGRFV EFYYWDSYWV MEGLLLSEMA ETVKGMLQNF LDLVKTYGHV PNGGRVYYLQ RSQPPLLTLM MDCYLTHTND TAFLQENIET LALELDFWTK NRTVSVSLEG KNYLLNRYYV PYGGPRPESY SKDVELADTL PEGDREALWA ELKAGAESGW DFSSRWLIGG PNPNSLSGIR TSKLVPVDLN AFLCQAEELM SNFYSRLGND SQATKYRILR SQRLAALNTV LWDEQTGAWF DYDLEKKKKN REFYPSNLTP LWAGCFSDPG VADKALKYLE DNRILTYQYG IPTSLQKTGQ QWDFPNAWAP LQDLVIRGLA KAPLRRAQEV AFQLAQNWIR TNFDVYSQKS AMYEKYDVSN GGQPGGGGEY EVQEGFGWTN GVVLMLLDRY GDRLTSGAKL AFLEPHCLAA TLLPSLLLSL LPW
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