About Embryonal Fyn-associated substrate
Embryonal Fyn-associated substrate (EFS) is a protein
from Homo sapiens identified by UniProt accession
O43281, 561 residues long.
MolForge cross-references it against 0 known binders and
253 disease associations.
Target properties
| Protein name | Embryonal Fyn-associated substrate |
|---|
| UniProt accession | O43281 |
|---|
| Gene | EFS |
|---|
| Organism | Homo sapiens |
|---|
| Length | 561 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (253)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- brain measurement · score 0.21
- cortical surface area measurement · score 0.17
- isolated agammaglobulinemia · score 0.07
- severe combined immunodeficiency due to CARD11 deficiency · score 0.06
- Autosomal recessive early-onset inflammatory bowel disease · score 0.06
- hyper-IgE recurrent infection syndrome 5, autosomal recessive · score 0.06
- common variable immunodeficiency · score 0.06
- immunodeficiency 89 and autoimmunity · score 0.06
- autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43281-F1 | alphafold | PREDICTED | 61.46 | — |
Amino-acid sequence (561 residues)
MAIATSTQLA RALYDNTAES PQELSFRRGD VLRVLQREGA GGLDGWCLCS LHGQQGIVPA NRVKLLPAGP APKPSLSPAS PAQPGSPYPA PDHSNEDQEV YVVPPPARPC PTSGPPAGPC PPSPDLIYKI PRASGTQLAA PRDALEVYDV PPTALRVPSS GPYDCPASFS HPLTRVAPQP PGEDDAPYDV PLTPKPPAEL EPDLEWEGGR EPGPPIYAAP SNLKRASALL NLYEAPEELL ADGEGGGTDE GIYDVPLLGP EAPPSPEPPG ALASHDQDTL AQLLARSPPP PHRPRLPSAE SLSRRPLPAL PVPEAPSPSP VPSPAPGRKG SIQDRPLPPP PPRLPGYGGP KVEGDPEGRE MEDDPAGHHN EYEGIPMAEE YDYVHLKGMD KAQGSRPPDQ ACTGDPELPE RGMPAPQEAL SPGEPLVVST GDLQLLYFYA GQCQSHYSAL QAAVAALMSS TQANQPPRLF VPHSKRVVVA AHRLVFVGDT LGRLAASAPL RAQVRAAGTA LGQALRATVL AVKGAALGYP SSPAIQEMVQ CVTELAGQAL QFTTLLTSLA P
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