Beta-1,4-galactosyltransferase 5 (B4GALT5)

About Beta-1,4-galactosyltransferase 5

Beta-1,4-galactosyltransferase 5 (B4GALT5) is a protein from Homo sapiens identified by UniProt accession O43286, 388 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.

Target properties

Protein name	Beta-1,4-galactosyltransferase 5
UniProt accession	O43286
Gene	B4GALT5
Organism	Homo sapiens
Length	388 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (64)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.50
lysosomal storage disease · score 0.37
FEV/FVC ratio · score 0.27
brain measurement · score 0.27
diastolic blood pressure · score 0.25
low density lipoprotein cholesterol measurement · score 0.20
hepatocellular carcinoma · score 0.09
drug use measurement · score 0.07
major depressive disorder · score 0.06
obsessive-compulsive disorder · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43286-F1	alphafold	PREDICTED	87.67	—

Amino-acid sequence (388 residues)

MRARRGLLRL PRRSLLAALF FFSLSSSLLY FVYVAPGIVN TYLFMMQAQG ILIRDNVRTI GAQVYEQVLR SAYAKRNSSV NDSDYPLDLN HSETFLQTTT FLPEDFTYFA NHTCPERLPS MKGPIDINMS EIGMDYIHEL FSKDPTIKLG GHWKPSDCMP RWKVAILIPF RNRHEHLPVL FRHLLPMLQR QRLQFAFYVV EQVGTQPFNR AMLFNVGFQE AMKDLDWDCL IFHDVDHIPE SDRNYYGCGQ MPRHFATKLD KYMYLLPYTE FFGGVSGLTV EQFRKINGFP NAFWGWGGED DDLWNRVQNA GYSVSRPEGD TGKYKSIPHH HRGEVQFLGR YALLRKSKER QGLDGLNNLN YFANITYDAL YKNITVNLTP ELAQVNEY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards