About GPI-anchor transamidase component GPAA1
GPI-anchor transamidase component GPAA1 (GPAA1) is a protein
from Homo sapiens identified by UniProt accession
O43292, 621 residues long.
MolForge cross-references it against 0 known binders and
65 disease associations.
Target properties
| Protein name | GPI-anchor transamidase component GPAA1 |
|---|
| UniProt accession | O43292 |
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| Gene | GPAA1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 621 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (65)
Diseases linked to this target (Open Targets).
- glycosylphosphatidylinositol biosynthesis defect 15 · score 0.80
- genetic disorder · score 0.41
- Global developmental delay · score 0.37
- urinary bladder cancer · score 0.19
- mean corpuscular volume · score 0.16
- mean corpuscular hemoglobin concentration · score 0.11
- serum metabolite measurement · score 0.11
- mean corpuscular hemoglobin · score 0.10
- metabolite measurement · score 0.09
- hepatocellular carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43292-F1 | alphafold | PREDICTED | 87.23 | — |
Amino-acid sequence (621 residues)
MGLLSDPVRR RALARLVLRL NAPLCVLSYV AGIAWFLALV FPPLTQRTYM SENAMGSTMV EEQFAGGDRA RAFARDFAAH RKKSGALPVA WLERTMRSVG LEVYTQSFSR KLPFPDETHE RYMVSGTNVY GILRAPRAAS TESLVLTVPC GSDSTNSQAV GLLLALAAHF RGQIYWAKDI VFLVTEHDLL GTEAWLEAYH DVNVTGMQSS PLQGRAGAIQ AAVALELSSD VVTSLDVAVE GLNGQLPNLD LLNLFQTFCQ KGGLLCTLQG KLQPEDWTSL DGPLQGLQTL LLMVLRQASG RPHGSHGLFL RYRVEALTLR GINSFRQYKY DLVAVGKALE GMFRKLNHLL ERLHQSFFLY LLPGLSRFVS IGLYMPAVGF LLLVLGLKAL ELWMQLHEAG MGLEEPGGAP GPSVPLPPSQ GVGLASLVAP LLISQAMGLA LYVLPVLGQH VATQHFPVAE AEAVVLTLLA IYAAGLALPH NTHRVVSTQA PDRGWMALKL VALIYLALQL GCIALTNFSL GFLLATTMVP TAALAKPHGP RTLYAALLVL TSPAATLLGS LFLWRELQEA PLSLAEGWQL FLAALAQGVL EHHTYGALLF PLLSLGLYPC WLLFWNVLFW K
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