About Death-associated protein kinase 3
Death-associated protein kinase 3 (DAPK3) is a protein
from Homo sapiens identified by UniProt accession
O43293, 454 residues long.
MolForge cross-references it against 0 known binders and
98 disease associations.
Target properties
| Protein name | Death-associated protein kinase 3 |
|---|
| UniProt accession | O43293 |
|---|
| Gene | DAPK3 |
|---|
| Organism | Homo sapiens |
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| Length | 454 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (9)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (98)
Diseases linked to this target (Open Targets).
- low grade glioma · score 0.23
- neurodegenerative disease · score 0.21
- creatinine measurement · score 0.18
- cutaneous melanoma · score 0.15
- esophageal cancer · score 0.15
- glomerular filtration rate · score 0.13
- head and neck squamous cell carcinoma · score 0.12
- neoplasm · score 0.10
- attention deficit hyperactivity disorder · score 0.09
- attention deficit-hyperactivity disorder 8 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43293-F1 | alphafold | PREDICTED | 87.01 | — |
Amino-acid sequence (454 residues)
MSTFRQEDVE DHYEMGEELG SGQFAIVRKC RQKGTGKEYA AKFIKKRRLS SSRRGVSREE IEREVNILRE IRHPNIITLH DIFENKTDVV LILELVSGGE LFDFLAEKES LTEDEATQFL KQILDGVHYL HSKRIAHFDL KPENIMLLDK NVPNPRIKLI DFGIAHKIEA GNEFKNIFGT PEFVAPEIVN YEPLGLEADM WSIGVITYIL LSGASPFLGE TKQETLTNIS AVNYDFDEEY FSNTSELAKD FIRRLLVKDP KRRMTIAQSL EHSWIKAIRR RNVRGEDSGR KPERRRLKTT RLKEYTIKSH SSLPPNNSYA DFERFSKVLE EAAAAEEGLR ELQRSRRLCH EDVEALAAIY EEKEAWYREE SDSLGQDLRR LRQELLKTEA LKRQAQEEAK GALLGTSGLK RRFSRLENRY EALAKQVASE MRFVQDLVRA LEQEKLQGVE CGLR
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