About Transforming growth factor beta-1-induced transcript 1 protein
Transforming growth factor beta-1-induced transcript 1 protein (TGFB1I1) is a protein
from Homo sapiens identified by UniProt accession
O43294, 461 residues long.
MolForge cross-references it against 0 known binders and
128 disease associations.
Target properties
| Protein name | Transforming growth factor beta-1-induced transcript 1 protein |
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| UniProt accession | O43294 |
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| Gene | TGFB1I1 |
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| Organism | Homo sapiens |
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| Length | 461 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (128)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.32
- Glycosuria · score 0.22
- parental genotype effect measurement · score 0.22
- gestational blood glucose measurement · score 0.22
- fetal genotype effect measurement · score 0.18
- neoplasm · score 0.10
- mucous membrane pemphigoid · score 0.09
- hepatocellular carcinoma · score 0.08
- ganglioneuroma · score 0.08
- MODY · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43294-F1 | alphafold | PREDICTED | 71.14 | — |
Amino-acid sequence (461 residues)
MEDLDALLSD LETTTSHMPR SGAPKERPAE PLTPPPSYGH QPQTGSGESS GASGDKDHLY STVCKPRSPK PAAPAAPPFS SSSGVLGTGL CELDRLLQEL NATQFNITDE IMSQFPSSKV ASGEQKEDQS EDKKRPSLPS SPSPGLPKAS ATSATLELDR LMASLSDFRV QNHLPASGPT QPPVVSSTNE GSPSPPEPTG KGSLDTMLGL LQSDLSRRGV PTQAKGLCGS CNKPIAGQVV TALGRAWHPE HFVCGGCSTA LGGSSFFEKD GAPFCPECYF ERFSPRCGFC NQPIRHKMVT ALGTHWHPEH FCCVSCGEPF GDEGFHEREG RPYCRRDFLQ LFAPRCQGCQ GPILDNYISA LSALWHPDCF VCRECFAPFS GGSFFEHEGR PLCENHFHAR RGSLCATCGL PVTGRCVSAL GRRFHPDHFT CTFCLRPLTK GSFQERAGKP YCQPCFLKLF G
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