About Zinc finger and BTB domain-containing protein 43
Zinc finger and BTB domain-containing protein 43 (ZBTB43) is a protein
from Homo sapiens identified by UniProt accession
O43298, 467 residues long.
MolForge cross-references it against 0 known binders and
35 disease associations.
Target properties
| Protein name | Zinc finger and BTB domain-containing protein 43 |
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| UniProt accession | O43298 |
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| Gene | ZBTB43 |
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| Organism | Homo sapiens |
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| Length | 467 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (35)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.35
- vital capacity · score 0.18
- body mass index · score 0.06
- body weight · score 0.05
- brain measurement · score 0.05
- MODY · score 0.04
- hyperinsulinism due to INSR deficiency · score 0.04
- 3-hydroxy-3-methylglutaryl-CoA synthase deficiency · score 0.04
- exercise-induced hyperinsulinism · score 0.04
- glycogen storage disorder due to hepatic glycogen synthase deficiency · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43298-F1 | alphafold | PREDICTED | 56.91 | — |
Amino-acid sequence (467 residues)
MEPGTNSFRV EFPDFSSTIL QKLNQQRQQG QLCDVSIVVQ GHIFRAHKAV LAASSPYFCD QVLLKNSRRI VLPDVMNPRV FENILLSSYT GRLVMPAPEI VSYLTAASFL QMWHVVDKCT EVLEGNPTVL CQKLNHGSDH QSPSSSSYNG LVESFELGSG GHTDFPKAQE LRDGENEEES TKDELSSQLT EHEYLPSNSS TEHDRLSTEM ASQDGEEGAS DSAEFHYTRP MYSKPSIMAH KRWIHVKPER LEQACEGMDV HATYDEHQVT ESINTVQTEH TVQPSGVEED FHIGEKKVEA EFDEQADESN YDEQVDFYGS SMEEFSGERS DGNLIGHRQE AALAAGYSEN IEMVTGIKEE ASHLGFSATD KLYPCQCGKS FTHKSQRDRH MSMHLGLRPY GCGVCGKKFK MKHHLVGHMK IHTGIKPYEC NICAKRFMWR DSFHRHVTSC TKSYEAAKAE QNTTEAN
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