About AP-5 complex subunit zeta-1
AP-5 complex subunit zeta-1 (AP5Z1) is a protein
from Homo sapiens identified by UniProt accession
O43299, 807 residues long.
MolForge cross-references it against 0 known binders and
32 disease associations.
Target properties
| Protein name | AP-5 complex subunit zeta-1 |
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| UniProt accession | O43299 |
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| Gene | AP5Z1 |
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| Organism | Homo sapiens |
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| Length | 807 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (32)
Diseases linked to this target (Open Targets).
- Autosomal recessive spastic paraplegia type 48 · score 0.76
- hereditary spastic paraplegia 48 · score 0.66
- hereditary spastic paraplegia · score 0.60
- hereditary sensory and autonomic neuropathy with spastic paraplegia · score 0.41
- neurodegenerative disease · score 0.37
- genetic disorder · score 0.34
- parental longevity · score 0.21
- hypothyroidism · score 0.13
- Spastic paraplegia · score 0.12
- pathological myopia · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43299-F1 | alphafold | PREDICTED | 84.90 | — |
Amino-acid sequence (807 residues)
MFSAGAESLL HQAREIQDEE LKKFCSRICK LLQAEDLGPD TLDSLQRLFL IISATKYSRR LEKTCVDLLQ ATLGLPACPE QLQVLCAAIL REMSPSDSLS LAWDHTQNSR QLSLVASVLL AQGDRNEEVR AVGQGVLRAL ESRQPEGPSL RHLLPVMAKV VVLSPGTLQE DQATLLSKRL VDWLRYASLQ QGLPHSGGFF STPRARQPGP VTEVDGAVAT DFFTVLSSGH RFTDDQWLNV QAFSMLRAWL LHSGPEGPGT LDTDDRSEQE GSTLSVISAT SSAGRLLPPR ERLREVAFEY CQRLIEQSNR RALRKGDSDL QKACLVEAVL VLDVLCRQDP SFLYRSLSCL KALHGRVRGD PASVRVLLPL AHFFLSHGEA AAVDSEAVYQ HLFTRIPVEQ FHSPMLAFEF IQFCRDNLHL FSGHLSTLRL SFPNLFKFLA WNSPPLTSEF VALLPALVDA GTALEMLHAL LDLPCLTAVL DLQLRSAPAA SERPLWDTSL RAPSCLEAFR DPQFQGLFQY LLRPKASGAT ERLAPLHQLL QPMAGCARVA QCAQAVPTLL QAFFSAVTQV ADGSLINQLA LLLLGRSDSL YPAPGYAAGV HSVLSSQFLA LCTLKPSLVV ELARDLLEFL GSVNGLCSRA SLVTSVVWAI GEYLSVTYDR RCTVEQINKF FEALEALLFE VTQCRPSAAL PRCPPQVVTV LMTTLTKLAS RSQDLIPRAS LLLSKMRTLA HSPATSSTHS EEGAEAIRTR ATELLTLLKM PSVAQFVLTP STEVCSPRYH RDANTALPLA LRTVSRLVER EAGLMPG
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