About Heat shock 70 kDa protein 12A
Heat shock 70 kDa protein 12A (HSPA12A) is a protein
from Homo sapiens identified by UniProt accession
O43301, 675 residues long.
MolForge cross-references it against 0 known binders and
109 disease associations.
Target properties
| Protein name | Heat shock 70 kDa protein 12A |
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| UniProt accession | O43301 |
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| Gene | HSPA12A |
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| Organism | Homo sapiens |
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| Length | 675 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (109)
Diseases linked to this target (Open Targets).
- systolic blood pressure · score 0.36
- cardiovascular disease · score 0.31
- cup-to-disc ratio measurement · score 0.27
- aspartate aminotransferase measurement · score 0.26
- type 2 diabetes mellitus · score 0.26
- wrist fracture · score 0.24
- body mass index · score 0.23
- attention deficit hyperactivity disorder · score 0.22
- freckles · score 0.22
- antisocial behaviour measurement · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43301-F1 | alphafold | PREDICTED | 84.34 | — |
Amino-acid sequence (675 residues)
MADKEAGGSD GPRETAPTSA YSSPARSLGD TGITPLSPSH IVNDTDSNVS EQQSFLVVVA VDFGTTSSGY AYSFTKEPEC IHVMRRWEGG DPGVSNQKTP TTILLTPERK FHSFGYAARD FYHDLDPNEA KQWLYLEKFK MKLHTTGDLT MDTDLTAANG KKVKALEIFA YALQYFKEQA LKELSDQAGS EFENSDVRWV ITVPAIWKQP AKQFMRQAAY QAGLASPENS EQLIIALEPE AASIYCRKLR LHQMIELSSK AAVNGYSGSD TVGAGFTQAK EHIRRNRQSR TFLVENVIGE IWSELEEGDK YVVVDSGGGT VDLTVHQIRL PEGHLKELYK ATGGPYGSLG VDYEFEKLLY KIFGEDFIEQ FKIKRPAAWV DLMIAFESRK RAAAPDRTNP LNITLPFSFI DYYKKFRGHS VEHALRKSNV DFVKWSSQGM LRMSPDAMNA LFKPTIDSII EHLRDLFQKP EVSTVKFLFL VGGFAEAPLL QQAVQAAFGD QCRIIIPQDV GLTILKGAVL FGLDPAVIKV RRSPLTYGVG VLNRYVEGKH PPEKLLVKDG TRWCTDVFDK FISADQSVAL GELVKRSYTP AKPSQLVIVI NIYSSEHDNV SFITDPGVKK CGTLRLDLTG TSGTAVPARR EIQTLMQFGD TEIKATAIDI ATSKSVKVGI DFLNY
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