About SEC14-like protein 5
SEC14-like protein 5 (SEC14L5) is a protein
from Homo sapiens identified by UniProt accession
O43304, 696 residues long.
MolForge cross-references it against 0 known binders and
70 disease associations.
Target properties
| Protein name | SEC14-like protein 5 |
|---|
| UniProt accession | O43304 |
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| Gene | SEC14L5 |
|---|
| Organism | Homo sapiens |
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| Length | 696 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (70)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.42
- platelet count · score 0.36
- platelet component distribution width · score 0.34
- protein measurement · score 0.28
- PHF-tau measurement · score 0.25
- Fuchs endothelial corneal dystrophy · score 0.07
- urate measurement · score 0.07
- bone density · score 0.07
- Lisch epithelial corneal dystrophy · score 0.07
- keratoconus 1 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43304-F1 | alphafold | PREDICTED | 78.46 | — |
Amino-acid sequence (696 residues)
MVQRYQSPVR VYKYPFELVM AAYEKRFPTC PQIPVFLGSE VLRESRSPDG AVHVVERSCR LRVDAPRLLR KIAGVEHVVF VQTNILNWKE RTLLIEAHNE TFANRVVVNE HCSYTVHPEN EDWTCFEQSA SLDIRSFFGF ENALEKIAMK QYTANVKRGK EVIEHYLNEL ISQGTSHIPR WTPAPVREED ARNQAGPRDP SSLEAHGPRS TLGPALEAVS MDGDKLDADY IERCLGHLTP MQESCLIQLR HWLQETHKGK IPKDEHILRF LRAHDFHLDK AREMLRQSLS WRKQHQVDLL LQTWQPPALL EEFYAGGWHY QDIDGRPLYI LRLGQMDTKG LMKAVGEEAL LRHVLSVNEE GQKRCEGSTR QLGRPISSWT CLLDLEGLNM RHLWRPGVKA LLRMIEVVED NYPETLGRLL IVRAPRVFPV LWTLISPFIN ENTRRKFLIY SGSNYQGPGG LVDYLDREVI PDFLGGESVC NVPEGGLVPK SLYMTEEEQE HTDQLWQWSE TYHSASVLRG APHEVAVEIL EGESVITWDF DILRGDVVFS LYHTKQAPRL GAREPGTRAS GQLIDKGWVL GRDYSRVEAP LVCREGESIQ GSHVTRWPGV YLLQWQMHSP PSSVACSLPG VDDVLTALHS PGPKCKLLYY CEVLASEDFR GSMSSLESCT SGFSQLSAAT SSSSSGQSHS SSLVSR
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