About Rho guanine nucleotide exchange factor 9
Rho guanine nucleotide exchange factor 9 (ARHGEF9) is a protein
from Homo sapiens identified by UniProt accession
O43307, 516 residues long.
MolForge cross-references it against 0 known binders and
76 disease associations.
Target properties
| Protein name | Rho guanine nucleotide exchange factor 9 |
|---|
| UniProt accession | O43307 |
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| Gene | ARHGEF9 |
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| Organism | Homo sapiens |
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| Length | 516 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (76)
Diseases linked to this target (Open Targets).
- developmental and epileptic encephalopathy, 8 · score 0.78
- developmental and epileptic encephalopathy · score 0.57
- genetic disorder · score 0.51
- Hyperekplexia - epilepsy · score 0.46
- X-linked intellectual disability - epilepsy · score 0.46
- Global developmental delay · score 0.37
- Neurodevelopmental delay · score 0.27
- cutaneous melanoma · score 0.22
- glioblastoma multiforme · score 0.21
- breast adenocarcinoma · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43307-F1 | alphafold | PREDICTED | 80.13 | — |
Amino-acid sequence (516 residues)
MTLLITGDSI VSAEAVWDHV TMANRELAFK AGDVIKVLDA SNKDWWWGQI DDEEGWFPAS FVRLWVNQED EVEEGPSDVQ NGHLDPNSDC LCLGRPLQNR DQMRANVINE IMSTERHYIK HLKDICEGYL KQCRKRRDMF SDEQLKVIFG NIEDIYRFQM GFVRDLEKQY NNDDPHLSEI GPCFLEHQDG FWIYSEYCNN HLDACMELSK LMKDSRYQHF FEACRLLQQM IDIAIDGFLL TPVQKICKYP LQLAELLKYT AQDHSDYRYV AAALAVMRNV TQQINERKRR LENIDKIAQW QASVLDWEGE DILDRSSELI YTGEMAWIYQ PYGRNQQRVF FLFDHQMVLC KKDLIRRDIL YYKGRIDMDK YEVVDIEDGR DDDFNVSMKN AFKLHNKETE EIHLFFAKKL EEKIRWLRAF REERKMVQED EKIGFEISEN QKRQAAMTVR KVPKQKGVNS ARSVPPSYPP PQDPLNHGQY LVPDGIAQSQ VFEFTEPKRS QSPFWQNFSR LTPFKK
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