About Zinc finger and SCAN domain-containing protein 12
Zinc finger and SCAN domain-containing protein 12 (ZSCAN12) is a protein
from Homo sapiens identified by UniProt accession
O43309, 611 residues long.
MolForge cross-references it against 0 known binders and
95 disease associations.
Target properties
| Protein name | Zinc finger and SCAN domain-containing protein 12 |
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| UniProt accession | O43309 |
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| Gene | ZSCAN12 |
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| Organism | Homo sapiens |
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| Length | 611 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (95)
Diseases linked to this target (Open Targets).
- neutrophil count · score 0.19
- hyperthyroidism · score 0.19
- sitting height measurement · score 0.17
- celiac disease · score 0.17
- lymphocyte count · score 0.14
- Malabsorption · score 0.14
- rheumatoid arthritis · score 0.13
- malabsorption syndrome · score 0.13
- diet measurement · score 0.13
- Myopia · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43309-F1 | alphafold | PREDICTED | 69.80 | — |
Amino-acid sequence (611 residues)
MASTWAIQAH MDQDEPLEVK IEEEKYTTRQ DWDLRKNNTH SREVFRQYFR QFCYQETSGP REALSRLREL CHQWLRPETH TKEQILELLV LEQFLTILPE ELQAWVQEQH PESGEEVVTV LEDLERELDE PGEQVSVHTG EQEMFLQETV RLRKEGEPSM SLQSMKAQPK YESPELESQQ EQVLDVETGN EYGNLKQEVS EEMEPHGKTS SKFENDMSKS ARCGETREPE EITEEPSACS REDKQPTCDE NGVSLTENSD HTEHQRICPG EESYGCDDCG KAFSQHSHLI EHQRIHTGDR PYKCEECGKA FRGRTVLIRH KIIHTGEKPY KCNECGKAFG RWSALNQHQR LHTGEKHYHC NDCGKAFSQK AGLFHHIKIH TRDKPYQCTQ CNKSFSRRSI LTQHQGVHTG AKPYECNECG KAFVYNSSLV SHQEIHHKEK CYQCKECGKS FSQSGLIQHQ RIHTGEKPYK CDVCEKAFIQ RTSLTEHQRI HTGERPYKCD KCGKAFTQRS VLTEHQRIHT GERPYKCDEC GNAFRGITSL IQHQRIHTGE KPYQCDECGK AFRQRSDLSK HQRIHNRRGT YVCKECGKSF RQNSALTQHQ TIHKGEKSVS V
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