About CBP80/20-dependent translation initiation factor
CBP80/20-dependent translation initiation factor (CTIF) is a protein
from Homo sapiens identified by UniProt accession
O43310, 598 residues long.
MolForge cross-references it against 0 known binders and
141 disease associations.
Target properties
| Protein name | CBP80/20-dependent translation initiation factor |
|---|
| UniProt accession | O43310 |
|---|
| Gene | CTIF |
|---|
| Organism | Homo sapiens |
|---|
| Length | 598 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (141)
Diseases linked to this target (Open Targets).
- erythrocyte count · score 0.44
- hemoglobin measurement · score 0.44
- hematocrit · score 0.42
- neurodegenerative disease · score 0.37
- mean corpuscular hemoglobin concentration · score 0.37
- red blood cell density measurement · score 0.34
- body height · score 0.31
- sitting height measurement · score 0.30
- PHF-tau measurement · score 0.28
- risk-taking behaviour · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43310-F1 | alphafold | PREDICTED | 62.30 | — |
Amino-acid sequence (598 residues)
MENSSAASAS SEAGSSRSQE IEELERFIDS YVLEYQVQGL LADKTEGDGE SERTQSHISQ WTADCSEPLD SSCSFSRGRA PPQQNGSKDN SLDMLGTDIW AANTFDSFSG ATWDLQPEKL DFTQFHRKVR HTPKQPLPHI DREGCGKGKL EDGDGINLND IEKVLPAWQG YHPMPHEVEI AHTKKLFRRR RNDRRRQQRP PGGNKPQQHG DHQPGSAKHN RDHQKSYQGG SAPHPSGRPT HHGYSQNRRW HHGNMKHPPG DKGEAGAHRN AKETMTIENP KLEDTAGDTG HSSLEAPRSP DTLAPVASER LPPQQSGGPE VETKRKDSIL PERIGERPKI TLLQSSKDRL RRRLKEKDEV AVETTTPQQN KMDKLIEILN SMRNNSSDVD TKLTTFMEEA QNSTNSEEML GEIVRTIYQK AVSDRSFAFT AAKLCDKMAL FMVEGTKFRS LLLNMLQKDF TVREELQQQD VERWLGFITF LCEVFGTMRS STGEPFRVLV CPIYTCLREL LQSQDVKEDA VLCCSMELQS TGRLLEEQLP EMMTELLASA RDKMLCPSES MLTRSLLLEV IELHANSWNP LTPPITQYYN RTIQKLTA
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