About Aquaporin-9
Aquaporin-9 (AQP9) is a protein
from Homo sapiens identified by UniProt accession
O43315, 295 residues long.
MolForge cross-references it against 0 known binders and
224 disease associations.
Target properties
| Protein name | Aquaporin-9 |
|---|
| UniProt accession | O43315 |
|---|
| Gene | AQP9 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 295 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (224)
Diseases linked to this target (Open Targets).
- triglyceride measurement · score 0.33
- glycine measurement · score 0.30
- high density lipoprotein cholesterol measurement · score 0.27
- coronary artery calcification · score 0.25
- inflammatory bowel disease · score 0.13
- serum metabolite measurement · score 0.13
- white matter microstructure measurement · score 0.12
- grip strength measurement · score 0.12
- hepatocellular carcinoma · score 0.11
- neoplasm · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43315-F1 | alphafold | PREDICTED | 91.54 | — |
Amino-acid sequence (295 residues)
MQPEGAEKGK SFKQRLVLKS SLAKETLSEF LGTFILIVLG CGCVAQAILS RGRFGGVITI NVGFSMAVAM AIYVAGGVSG GHINPAVSLA MCLFGRMKWF KLPFYVGAQF LGAFVGAATV FGIYYDGLMS FAGGKLLIVG ENATAHIFAT YPAPYLSLAN AFADQVVATM ILLIIVFAIF DSRNLGAPRG LEPIAIGLLI IVIASSLGLN SGCAMNPARD LSPRLFTALA GWGFEVFRAG NNFWWIPVVG PLVGAVIGGL IYVLVIEIHH PEPDSVFKTE QSEDKPEKYE LSVIM
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