Paired box protein Pax-4 (PAX4)

About Paired box protein Pax-4

Paired box protein Pax-4 (PAX4) is a protein from Homo sapiens identified by UniProt accession O43316, 350 residues long. MolForge cross-references it against 0 known binders and 143 disease associations.

Target properties

Protein name	Paired box protein Pax-4
UniProt accession	O43316
Gene	PAX4
Organism	Homo sapiens
Length	350 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (143)

Diseases linked to this target (Open Targets).

type 2 diabetes mellitus · score 0.61
MODY · score 0.60
diabetes mellitus · score 0.52
Drugs used in diabetes use measurement · score 0.38
hemoglobin A1 measurement · score 0.38
triglyceride measurement · score 0.37
type 1 diabetes mellitus · score 0.24
maturity-onset diabetes of the young · score 0.23
high density lipoprotein cholesterol measurement · score 0.21
diabetic ketoacidosis · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43316-F1	alphafold	PREDICTED	69.35	—

Amino-acid sequence (350 residues)

MHQDGISSMN QLGGLFVNGR PLPLDTRQQI VRLAVSGMRP CDISRILKVS NGCVSKILGR YYRTGVLEPK GIGGSKPRLA TPPVVARIAQ LKGECPALFA WEIQRQLCAE GLCTQDKTPS VSSINRVLRA LQEDQGLPCT RLRSPAVLAP AVLTPHSGSE TPRGTHPGTG HRNRTIFSPS QAEALEKEFQ RGQYPDSVAR GKLATATSLP EDTVRVWFSN RRAKWRRQEK LKWEMQLPGA SQGLTVPRVA PGIISAQQSP GSVPTAALPA LEPLGPSCYQ LCWATAPERC LSDTPPKACL KPCWDCGSFL LPVIAPSCVD VAWPCLDASL AHHLIGGAGK ATPTHFSHWP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards