About Mitogen-activated protein kinase kinase kinase 7
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7) is a protein
from Homo sapiens identified by UniProt accession
O43318, 606 residues long.
MolForge cross-references it against 0 known binders and
225 disease associations.
Target properties
| Protein name | Mitogen-activated protein kinase kinase kinase 7 |
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| UniProt accession | O43318 |
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| Gene | MAP3K7 |
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| Organism | Homo sapiens |
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| Length | 606 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (13)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (225)
Diseases linked to this target (Open Targets).
- cardiospondylocarpofacial syndrome · score 0.74
- frontometaphyseal dysplasia 2 · score 0.73
- frontometaphyseal dysplasia · score 0.60
- neurodegenerative disease · score 0.49
- COVID-19 · score 0.37
- serum gamma-glutamyl transferase measurement · score 0.29
- breast adenocarcinoma · score 0.28
- glioblastoma multiforme · score 0.28
- Delayed skeletal maturation · score 0.27
- ovarian cancer · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43318-F1 | alphafold | PREDICTED | 68.98 | — |
Amino-acid sequence (606 residues)
MSTASAASSS SSSSAGEMIE APSQVLNFEE IDYKEIEVEE VVGRGAFGVV CKAKWRAKDV AIKQIESESE RKAFIVELRQ LSRVNHPNIV KLYGACLNPV CLVMEYAEGG SLYNVLHGAE PLPYYTAAHA MSWCLQCSQG VAYLHSMQPK ALIHRDLKPP NLLLVAGGTV LKICDFGTAC DIQTHMTNNK GSAAWMAPEV FEGSNYSEKC DVFSWGIILW EVITRRKPFD EIGGPAFRIM WAVHNGTRPP LIKNLPKPIE SLMTRCWSKD PSQRPSMEEI VKIMTHLMRY FPGADEPLQY PCQYSDEGQS NSATSTGSFM DIASTNTSNK SDTNMEQVPA TNDTIKRLES KLLKNQAKQQ SESGRLSLGA SRGSSVESLP PTSEGKRMSA DMSEIEARIA ATTAYSKPKR GHRKTASFGN ILDVPEIVIS GNGQPRRRSI QDLTVTGTEP GQVSSRSSSP SVRMITTSGP TSEKPTRSHP WTPDDSTDTN GSDNSIPMAY LTLDHQLQPL APCPNSKESM AVFEQHCKMA QEYMKVQTEI ALLLQRKQEL VAELDQDEKD QQNTSRLVQE HKKLLDENKS LSTYYQQCKK QLEVIRSQQQ KRQGTS
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