Desert hedgehog protein (DHH)

About Desert hedgehog protein

Desert hedgehog protein (DHH) is a protein from Homo sapiens identified by UniProt accession O43323, 396 residues long. MolForge cross-references it against 0 known binders and 356 disease associations.

Target properties

Protein name	Desert hedgehog protein
UniProt accession	O43323
Gene	DHH
Organism	Homo sapiens
Length	396 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (356)

Diseases linked to this target (Open Targets).

46,XY gonadal dysgenesis-motor and sensory neuropathy syndrome · score 0.69
46,XY gonadal dysgenesis - motor and sensory neuropathy · score 0.69
46,XY complete gonadal dysgenesis · score 0.63
genetic disorder · score 0.18
breast adenocarcinoma · score 0.18
glioblastoma multiforme · score 0.18
neurodegenerative disease · score 0.17
disorder of sexual differentiation · score 0.12
Genetic 46,XY disorder of sex development · score 0.11
azoospermia · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43323-F1	alphafold	PREDICTED	84.35	—

Amino-acid sequence (396 residues)

MALLTNLLPL CCLALLALPA QSCGPGRGPV GRRRYARKQL VPLLYKQFVP GVPERTLGAS GPAEGRVARG SERFRDLVPN YNPDIIFKDE ENSGADRLMT ERCKERVNAL AIAVMNMWPG VRLRVTEGWD EDGHHAQDSL HYEGRALDIT TSDRDRNKYG LLARLAVEAG FDWVYYESRN HVHVSVKADN SLAVRAGGCF PGNATVRLWS GERKGLRELH RGDWVLAADA SGRVVPTPVL LFLDRDLQRR ASFVAVETEW PPRKLLLTPW HLVFAARGPA PAPGDFAPVF ARRLRAGDSV LAPGGDALRP ARVARVAREE AVGVFAPLTA HGTLLVNDVL ASCYAVLESH QWAHRAFAPL RLLHALGALL PGGAVQPTGM HWYSRLLYRL AEELLG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards