RNA-binding protein Musashi homolog 1 (MSI1)

About RNA-binding protein Musashi homolog 1

RNA-binding protein Musashi homolog 1 (MSI1) is a protein from Homo sapiens identified by UniProt accession O43347, 362 residues long. MolForge cross-references it against 0 known binders and 259 disease associations.

Target properties

Protein name	RNA-binding protein Musashi homolog 1
UniProt accession	O43347
Gene	MSI1
Organism	Homo sapiens
Length	362 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (259)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.56
breast carcinoma · score 0.29
BMI-adjusted hip circumference · score 0.26
rheumatoid arthritis · score 0.19
substance abuse · score 0.16
attention deficit hyperactivity disorder · score 0.16
antisocial behaviour measurement · score 0.16
lifestyle measurement · score 0.14
balding measurement · score 0.14
brain measurement · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43347-F1	alphafold	PREDICTED	64.48	—

Amino-acid sequence (362 residues)

METDAPQPGL ASPDSPHDPC KMFIGGLSWQ TTQEGLREYF GQFGEVKECL VMRDPLTKRS RGFGFVTFMD QAGVDKVLAQ SRHELDSKTI DPKVAFPRRA QPKMVTRTKK IFVGGLSVNT TVEDVKQYFE QFGKVDDAML MFDKTTNRHR GFGFVTFESE DIVEKVCEIH FHEINNKMVE CKKAQPKEVM SPTGSARGRS RVMPYGMDAF MLGIGMLGYP GFQATTYASR SYTGLAPGYT YQFPEFRVER TPLPSAPVLP ELTAIPLTAY GPMAAAAAAA AVVRGTGSHP WTMAPPPGST PSRTGGFLGT TSPGPMAELY GAANQDSGVS SYISAASPAP STGFGHSLGG PLIATAFTNG YH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards