About Homeobox protein Hox-A2
Homeobox protein Hox-A2 (HOXA2) is a protein
from Homo sapiens identified by UniProt accession
O43364, 376 residues long.
MolForge cross-references it against 0 known binders and
113 disease associations.
Target properties
| Protein name | Homeobox protein Hox-A2 |
|---|
| UniProt accession | O43364 |
|---|
| Gene | HOXA2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 376 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (113)
Diseases linked to this target (Open Targets).
- Bilateral microtia - deafness - cleft palate · score 0.68
- bilateral microtia-deafness-cleft palate syndrome · score 0.66
- microtia · score 0.38
- tonsillectomy risk measurement · score 0.30
- breast adenocarcinoma · score 0.22
- genetic disorder · score 0.19
- head and neck squamous cell carcinoma · score 0.15
- peak expiratory flow · score 0.10
- systolic blood pressure · score 0.09
- diastolic blood pressure · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43364-F1 | alphafold | PREDICTED | 56.98 | — |
Amino-acid sequence (376 residues)
MNYEFEREIG FINSQPSLAE CLTSFPPVAD TFQSSSIKTS TLSHSTLIPP PFEQTIPSLN PGSHPRHGAG GRPKPSPAGS RGSPVPAGAL QPPEYPWMKE KKAAKKTALL PAAAAAATAA ATGPACLSHK ESLEIADGSG GGSRRLRTAY TNTQLLELEK EFHFNKYLCR PRRVEIAALL DLTERQVKVW FQNRRMKHKR QTQCKENQNS EGKCKSLEDS EKVEEDEEEK TLFEQALSVS GALLEREGYT FQQNALSQQQ APNGHNGDSQ SFPVSPLTSN EKNLKHFQHQ SPTVPNCLST MGQNCGAGLN NDSPEALEVP SLQDFSVFST DSCLQLSDAV SPSLPGSLDS PVDISADSLD FFTDTLTTID LQHLNY
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