Homeobox protein Hox-A3 (HOXA3)

About Homeobox protein Hox-A3

Homeobox protein Hox-A3 (HOXA3) is a protein from Homo sapiens identified by UniProt accession O43365, 443 residues long. MolForge cross-references it against 0 known binders and 104 disease associations.

Target properties

Protein name	Homeobox protein Hox-A3
UniProt accession	O43365
Gene	HOXA3
Organism	Homo sapiens
Length	443 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (104)

Diseases linked to this target (Open Targets).

monocyte count · score 0.35
neurodegenerative disease · score 0.25
lymphocyte count · score 0.25
platelet count · score 0.24
diastolic blood pressure · score 0.24
systolic blood pressure · score 0.24
breast adenocarcinoma · score 0.22
leukocyte count · score 0.22
myeloid white cell count · score 0.22
heel bone mineral density · score 0.21

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43365-F1	alphafold	PREDICTED	57.85	—

Amino-acid sequence (443 residues)

MQKATYYDSS AIYGGYPYQA ANGFAYNANQ QPYPASAALG ADGEYHRPAC SLQSPSSAGG HPKAHELSEA CLRTLSAPPS QPPSLGEPPL HPPPPQAAPP APQPPQPAPQ PPAPTPAAPP PPSSASPPQN ASNNPTPANA AKSPLLNSPT VAKQIFPWMK ESRQNTKQKT SSSSSGESCA GDKSPPGQAS SKRARTAYTS AQLVELEKEF HFNRYLCRPR RVEMANLLNL TERQIKIWFQ NRRMKYKKDQ KGKGMLTSSG GQSPSRSPVP PGAGGYLNSM HSLVNSVPYE PQSPPPFSKP PQGTYGLPPA SYPASLPSCA PPPPPQKRYT AAGAGAGGTP DYDPHAHGLQ GNGSYGTPHI QGSPVFVGGS YVEPMSNSGP ALFGLTHLPH AASGAMDYGG AGPLGSGHHH GPGPGEPHPT YTDLTGHHPS QGRIQEAPKL THL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards