About Heterogeneous nuclear ribonucleoprotein R
Heterogeneous nuclear ribonucleoprotein R (HNRNPR) is a protein
from Homo sapiens identified by UniProt accession
O43390, 633 residues long.
MolForge cross-references it against 0 known binders and
145 disease associations.
Target properties
| Protein name | Heterogeneous nuclear ribonucleoprotein R |
|---|
| UniProt accession | O43390 |
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| Gene | HNRNPR |
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| Organism | Homo sapiens |
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| Length | 633 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (145)
Diseases linked to this target (Open Targets).
- Intellectual disability · score 0.55
- Global developmental delay · score 0.46
- Secondary microcephaly · score 0.46
- Seizure · score 0.46
- genetic disorder · score 0.44
- neurodegenerative disease · score 0.37
- syndromic intellectual disability · score 0.37
- monocyte count · score 0.32
- BMI-adjusted waist circumference · score 0.23
- monocyte percentage of leukocytes · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43390-F1 | alphafold | PREDICTED | 68.73 | — |
Amino-acid sequence (633 residues)
MANQVNGNAV QLKEEEEPMD TSSVTHTEHY KTLIEAGLPQ KVAERLDEIF QTGLVAYVDL DERAIDALRE FNEEGALSVL QQFKESDLSH VQNKSAFLCG VMKTYRQREK QGSKVQESTK GPDEAKIKAL LERTGYTLDV TTGQRKYGGP PPDSVYSGVQ PGIGTEVFVG KIPRDLYEDE LVPLFEKAGP IWDLRLMMDP LSGQNRGYAF ITFCGKEAAQ EAVKLCDSYE IRPGKHLGVC ISVANNRLFV GSIPKNKTKE NILEEFSKVT EGLVDVILYH QPDDKKKNRG FCFLEYEDHK SAAQARRRLM SGKVKVWGNV VTVEWADPVE EPDPEVMAKV KVLFVRNLAT TVTEEILEKS FSEFGKLERV KKLKDYAFVH FEDRGAAVKA MDEMNGKEIE GEEIEIVLAK PPDKKRKERQ AARQASRSTA YEDYYYHPPP RMPPPIRGRG RGGGRGGYGY PPDYYGYEDY YDDYYGYDYH DYRGGYEDPY YGYDDGYAVR GRGGGRGGRG APPPPRGRGA PPPRGRAGYS QRGAPLGPPR GSRGGRGGPA QQQRGRGSRG SRGNRGGNVG GKRKADGYNQ PDSKRRQTNN QQNWGSQPIA QQPLQQGGDY SGNYGYNNDN QEFYQDTYGQ QWK
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