About U4/U6 small nuclear ribonucleoprotein Prp3
U4/U6 small nuclear ribonucleoprotein Prp3 (PRPF3) is a protein
from Homo sapiens identified by UniProt accession
O43395, 683 residues long.
MolForge cross-references it against 0 known binders and
152 disease associations.
Target properties
| Protein name | U4/U6 small nuclear ribonucleoprotein Prp3 |
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| UniProt accession | O43395 |
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| Gene | PRPF3 |
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| Organism | Homo sapiens |
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| Length | 683 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (152)
Diseases linked to this target (Open Targets).
- retinitis pigmentosa · score 0.71
- Retinal dystrophy · score 0.46
- autosomal dominant retinitis pigmentosa · score 0.41
- neurodegenerative disease · score 0.35
- genetic disorder · score 0.19
- basophil count · score 0.10
- age-related macular degeneration · score 0.08
- hepatocellular carcinoma · score 0.08
- X-linked retinal dysplasia · score 0.08
- choroidal dystrophy, central areolar, 1 · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43395-F1 | alphafold | PREDICTED | 73.23 | — |
Amino-acid sequence (683 residues)
MALSKRELDE LKPWIEKTVK RVLGFSEPTV VTAALNCVGK GMDKKKAADH LKPFLDDSTL RFVDKLFEAV EEGRSSRHSK SSSDRSRKRE LKEVFGDDSE ISKESSGVKK RRIPRFEEVE EEPEVIPGPP SESPGMLTKL QIKQMMEAAT RQIEERKKQL SFISPPTPQP KTPSSSQPER LPIGNTIQPS QAATFMNDAI EKARKAAELQ ARIQAQLALK PGLIGNANMV GLANLHAMGI APPKVELKDQ TKPTPLILDE QGRTVDATGK EIELTHRMPT LKANIRAVKR EQFKQQLKEK PSEDMESNTF FDPRVSIAPS QRQRRTFKFH DKGKFEKIAQ RLRTKAQLEK LQAEISQAAR KTGIHTSTRL ALIAPKKELK EGDIPEIEWW DSYIIPNGFD LTEENPKRED YFGITNLVEH PAQLNPPVDN DTPVTLGVYL TKKEQKKLRR QTRREAQKEL QEKVRLGLMP PPEPKVRISN LMRVLGTEAV QDPTKVEAHV RAQMAKRQKA HEEANAARKL TAEQRKVKKI KKLKEDISQG VHISVYRVRN LSNPAKKFKI EANAGQLYLT GVVVLHKDVN VVVVEGGPKA QKKFKRLMLH RIKWDEQTSN TKGDDDEESD EEAVKKTNKC VLVWEGTAKD RSFGEMKFKQ CPTENMAREH FKKHGAEHYW DLALSESVLE STD
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