About ER membrane protein complex subunit 8
ER membrane protein complex subunit 8 (EMC8) is a protein
from Homo sapiens identified by UniProt accession
O43402, 210 residues long.
MolForge cross-references it against 0 known binders and
56 disease associations.
Target properties
| Protein name | ER membrane protein complex subunit 8 |
|---|
| UniProt accession | O43402 |
|---|
| Gene | EMC8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 210 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (56)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.41
- eosinophil percentage of leukocytes · score 0.33
- arterial stiffness measurement · score 0.32
- monocyte count · score 0.32
- sum of eosinophil and basophil counts · score 0.24
- eosinophil percentage of granulocytes · score 0.12
- alcohol consumption measurement · score 0.10
- PR interval · score 0.10
- neutrophil count · score 0.08
- diverticulitis · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43402-F1 | alphafold | PREDICTED | 91.29 | — |
Amino-acid sequence (210 residues)
MPGVKLTTQA YCKMVLHGAK YPHCAVNGLL VAEKQKPRKE HLPLGGPGAH HTLFVDCIPL FHGTLALAPM LEVALTLIDS WCKDHSYVIA GYYQANERVK DASPNQVAEK VASRIAEGFS DTALIMVDNT KFTMDCVAPT IHVYEHHENR WRCRDPHHDY CEDWPEAQRI SASLLDSRSY ETLVDFDNHL DDIRNDWTNP EINKAVLHLC
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