Cochlin (COCH)

About Cochlin

Cochlin (COCH) is a protein from Homo sapiens identified by UniProt accession O43405, 550 residues long. MolForge cross-references it against 0 known binders and 116 disease associations.

Target properties

Protein name	Cochlin
UniProt accession	O43405
Gene	COCH
Organism	Homo sapiens
Length	550 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (116)

Diseases linked to this target (Open Targets).

deafness · score 0.67
autosomal dominant nonsyndromic hearing loss · score 0.65
hearing loss, autosomal recessive 110 · score 0.62
nonsyndromic genetic hearing loss · score 0.49
Rare genetic deafness · score 0.45
cortical thickness · score 0.41
cortical surface area measurement · score 0.37
blood protein measurement · score 0.36
Hearing impairment · score 0.35
Sensorineural hearing impairment · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43405-F1	alphafold	PREDICTED	85.43	—

Amino-acid sequence (550 residues)

MSAAWIPALG LGVCLLLLPG PAGSEGAAPI AITCFTRGLD IRKEKADVLC PGGCPLEEFS VYGNIVYASV SSICGAAVHR GVISNSGGPV RVYSLPGREN YSSVDANGIQ SQMLSRWSAS FTVTKGKSST QEATGQAVST AHPPTGKRLK KTPEKKTGNK DCKADIAFLI DGSFNIGQRR FNLQKNFVGK VALMLGIGTE GPHVGLVQAS EHPKIEFYLK NFTSAKDVLF AIKEVGFRGG NSNTGKALKH TAQKFFTVDA GVRKGIPKVV VVFIDGWPSD DIEEAGIVAR EFGVNVFIVS VAKPIPEELG MVQDVTFVDK AVCRNNGFFS YHMPNWFGTT KYVKPLVQKL CTHEQMMCSK TCYNSVNIAF LIDGSSSVGD SNFRLMLEFV SNIAKTFEIS DIGAKIAAVQ FTYDQRTEFS FTDYSTKENV LAVIRNIRYM SGGTATGDAI SFTVRNVFGP IRESPNKNFL VIVTDGQSYD DVQGPAAAAH DAGITIFSVG VAWAPLDDLK DMASKPKESH AFFTREFTGL EPIVSDVIRG ICRDFLESQQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards