ERI1 exoribonuclease 3 (ERI3)

About ERI1 exoribonuclease 3

ERI1 exoribonuclease 3 (ERI3) is a protein from Homo sapiens identified by UniProt accession O43414, 337 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.

Target properties

Protein name	ERI1 exoribonuclease 3
UniProt accession	O43414
Gene	ERI3
Organism	Homo sapiens
Length	337 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (17)

Diseases linked to this target (Open Targets).

diet measurement · score 0.10
self reported educational attainment · score 0.08
brain measurement · score 0.07
neuroticism measurement · score 0.06
infection · score 0.06
infect · score 0.06
mathematical ability · score 0.03
heart rate response to recovery post exercise · score 0.03
heart rate response to exercise · score 0.03
reaction time measurement · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43414-F1	alphafold	PREDICTED	73.76	—

Amino-acid sequence (337 residues)

MATASPAADG GRGRPWEGGL VSWPPAPPLT LPWTWMGPSW GQHPGHWGFP ALTEPSASPA AGLGIFEVRR VLDASGCSML APLQTGAARF SSYLLSRARK VLGSHLFSPC GVPEFCSIST RKLAAHGFGA SMAAMVSFPP QRYHYFLVLD FEATCDKPQI HPQEIIEFPI LKLNGRTMEI ESTFHMYVQP VVHPQLTPFC TELTGIIQAM VDGQPSLQQV LERVDEWMAK EGLLDPNVKS IFVTCGDWDL KVMLPGQCQY LGLPVADYFK QWINLKKAYS FAMGCWPKNG LLDMNKGLSL QHIGRPHSGI DDCKNIANIM KTLAYRGFIF KQTSKPF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards