About 52 kDa repressor of the inhibitor of the protein kinase
52 kDa repressor of the inhibitor of the protein kinase (THAP12) is a protein
from Homo sapiens identified by UniProt accession
O43422, 761 residues long.
MolForge cross-references it against 0 known binders and
26 disease associations.
Target properties
| Protein name | 52 kDa repressor of the inhibitor of the protein kinase |
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| UniProt accession | O43422 |
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| Gene | THAP12 |
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| Organism | Homo sapiens |
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| Length | 761 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (26)
Diseases linked to this target (Open Targets).
- body height · score 0.26
- Eczematoid dermatitis · score 0.07
- MODY · score 0.06
- red blood cell density measurement · score 0.06
- hyperproinsulinemia · score 0.04
- myeloid white cell count · score 0.04
- Glycogen storage disease due to hepatic glycogen synthase deficiency · score 0.04
- glycogen storage disorder due to hepatic glycogen synthase deficiency · score 0.04
- monocyte count · score 0.03
- Crigler-Najjar syndrome type 2 · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43422-F1 | alphafold | PREDICTED | 83.80 | — |
Amino-acid sequence (761 residues)
MPNFCAAPNC TRKSTQSDLA FFRFPRDPAR CQKWVENCRR ADLEDKTPDQ LNKHYRLCAK HFETSMICRT SPYRTVLRDN AIPTIFDLTS HLNNPHSRHR KRIKELSEDE IRTLKQKKID ETSEQEQKHK ETNNSNAQNP SEEEGEGQDE DILPLTLEEK ENKEYLKSLF EILILMGKQN IPLDGHEADE IPEGLFTPDN FQALLECRIN SGEEVLRKRF ETTAVNTLFC SKTQQRQMLE ICESCIREET LREVRDSHFF SIITDDVVDI AGEEHLPVLV RFVDESHNLR EEFIGFLPYE ADAEILAVKF HTMITEKWGL NMEYCRGQAY IVSSGFSSKM KVVASRLLEK YPQAIYTLCS SCALNMWLAK SVPVMGVSVA LGTIEEVCSF FHRSPQLLLE LDNVISVLFQ NSKERGKELK EICHSQWTGR HDAFEILVEL LQALVLCLDG INSDTNIRWN NYIAGRAFVL CSAVSDFDFI VTIVVLKNVL SFTRAFGKNL QGQTSDVFFA AGSLTAVLHS LNEVMENIEV YHEFWFEEAT NLATKLDIQM KLPGKFRRAH QGNLESQLTS ESYYKETLSV PTVEHIIQEL KDIFSEQHLK ALKCLSLVPS VMGQLKFNTS EEHHADMYRS DLPNPDTLSA ELHCWRIKWK HRGKDIELPS TIYEALHLPD IKFFPNVYAL LKVLCILPVM KVENERYENG RKRLKAYLRN TLTDQRSSNL ALLNINFDIK HDLDLMVDTY IKLYTSKSEL PTDNSETVEN T
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