About Acidic fibroblast growth factor intracellular-binding protein
Acidic fibroblast growth factor intracellular-binding protein (FIBP) is a protein
from Homo sapiens identified by UniProt accession
O43427, 364 residues long.
MolForge cross-references it against 0 known binders and
89 disease associations.
Target properties
| Protein name | Acidic fibroblast growth factor intracellular-binding protein |
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| UniProt accession | O43427 |
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| Gene | FIBP |
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| Organism | Homo sapiens |
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| Length | 364 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (89)
Diseases linked to this target (Open Targets).
- tall stature-intellectual disability-renal anomalies syndrome · score 0.62
- coloboma · score 0.26
- learning disability · score 0.26
- Abnormal facial shape · score 0.26
- Overgrowth · score 0.26
- Macrocephaly · score 0.26
- Large hands · score 0.26
- genetic disorder · score 0.19
- Crohn's disease · score 0.14
- reticulocyte measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43427-F1 | alphafold | PREDICTED | 91.95 | — |
Amino-acid sequence (364 residues)
MTSELDIFVG NTTLIDEDVY RLWLDGYSVT DAVALRVRSG ILEQTGATAA VLQSDTMDHY RTFHMLERLL HAPPKLLHQL IFQIPPSRQA LLIERYYAFD EAFVREVLGK KLSKGTKKDL DDISTKTGIT LKSCRRQFDN FKRVFKVVEE MRGSLVDNIQ QHFLLSDRLA RDYAAIVFFA NNRFETGKKK LQYLSFGDFA FCAELMIQNW TLGAVGEAPT DPDSQMDDMD MDLDKEFLQD LKELKVLVAD KDLLDLHKSL VCTALRGKLG VFSEMEANFK NLSRGLVNVA AKLTHNKDVR DLFVDLVEKF VEPCRSDHWP LSDVRFFLNQ YSASVHSLDG FRHQALWDRY MGTLRGCLLR LYHD
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