About T-box transcription factor TBX1
T-box transcription factor TBX1 (TBX1) is a protein
from Homo sapiens identified by UniProt accession
O43435, 398 residues long.
MolForge cross-references it against 0 known binders and
549 disease associations.
Target properties
| Protein name | T-box transcription factor TBX1 |
|---|
| UniProt accession | O43435 |
|---|
| Gene | TBX1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 398 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (549)
Diseases linked to this target (Open Targets).
- 22q11.2 deletion syndrome · score 0.79
- Tetralogy of Fallot · score 0.60
- Shprintzen-Goldberg syndrome · score 0.49
- conotruncal heart malformations · score 0.42
- neurodegenerative disease · score 0.41
- Truncus arteriosus · score 0.38
- susceptibility to childhood ear infection measurement · score 0.37
- prostate carcinoma · score 0.37
- genetic disorder · score 0.37
- persistent truncus arteriosus · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43435-F1 | alphafold | PREDICTED | 68.17 | — |
Amino-acid sequence (398 residues)
MHFSTVTRDM EAFTASSLSS LGAAGGFPGA ASPGADPYGP REPPPPPPRY DPCAAAAPGA PGPPPPPHAY PFAPAAGAAT SAAAEPEGPG ASCAAAAKAP VKKNAKVAGV SVQLEMKALW DEFNQLGTEM IVTKAGRRMF PTFQVKLFGM DPMADYMLLM DFVPVDDKRY RYAFHSSSWL VAGKADPATP GRVHYHPDSP AKGAQWMKQI VSFDKLKLTN NLLDDNGHII LNSMHRYQPR FHVVYVDPRK DSEKYAEENF KTFVFEETRF TAVTAYQNHR ITQLKIASNP FAKGFRDCDP EDWPRNHRPG ALPLMSAFAR SRNPVASPTQ PSGTEKGGHV LKDKEVKAET SRNTPEREVE LLRDAGGCVN LGLPCPAECQ PFNTQGLVAG RTAGDRLC
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