Peptidyl-prolyl cis-trans isomerase H (PPIH)

About Peptidyl-prolyl cis-trans isomerase H

Peptidyl-prolyl cis-trans isomerase H (PPIH) is a protein from Homo sapiens identified by UniProt accession O43447, 177 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.

Target properties

Protein name	Peptidyl-prolyl cis-trans isomerase H
UniProt accession	O43447
Gene	PPIH
Organism	Homo sapiens
Length	177 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (23)

Diseases linked to this target (Open Targets).

severe acute respiratory syndrome · score 0.37
neurodegenerative disease · score 0.35
hepatocellular carcinoma · score 0.08
age at menopause · score 0.07
neoplasm · score 0.06
breast cancer · score 0.06
cancer · score 0.05
Red cell distribution width · score 0.03
systemic juvenile idiopathic arthritis · score 0.02
COVID-19 · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43447-F1	alphafold	PREDICTED	96.30	—

Amino-acid sequence (177 residues)

MAVANSSPVN PVVFFDVSIG GQEVGRMKIE LFADVVPKTA ENFRQFCTGE FRKDGVPIGY KGSTFHRVIK DFMIQGGDFV NGDGTGVASI YRGPFADENF KLRHSAPGLL SMANSGPSTN GCQFFITCSK CDWLDGKHVV FGKIIDGLLV MRKIENVPTG PNNKPKLPVV ISQCGEM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards